摘要
目的 采用新型缓释材料及固体分散技术制备三七总皂苷缓释片。方法 以人参皂苷Rg1和Rb1为指标 ,采用单因素法考察辅料对缓释作用的影响 ,并优化处方。结果 选择乙基纤维素(EC)为缓释部分的辅料 ,并以聚乙二醇 4 0 0 0 (PEG 4 0 0 0 )为速释部分的辅料。结论 初步实现了三七总皂苷缓释片的缓释效果。
Objective To find new slow-release adjuvant materials for preparing Slow-Release Total Notoginsenoside Tablets (SRTNT) by the solid-dispersing technology. Method Ginsenosides Rg 1 and Rb 1 were taken as criteria, the one-factor method was used to examine the influence of adjuvant materials on slow-release action, and the recipe of SRTNT was optimized at the same time.Result EC was chosen as a slow-release adjuvant material and PEG4000 as a rapid-release adjuvant material.Conclusion The slow-release effect of SRTNT is basically achieved.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2004年第3期75-77,共3页
Journal of Beijing University of Traditional Chinese Medicine
基金
北京中医药大学科研基金资助
关键词
三七总皂苷
缓释片
人参皂苷
高效液相
Total Notoginsenoside
Slow-Release Tablet
Ginsenosides Rg 1 and Rb 1
HPLC
