摘要
以两种分散方法制备不同粒径分布的188Re-硫化铼混悬液,采用涡旋法制得的大颗粒混悬液,粒径大于5μm的颗粒占55%,大于10μm的占19%;超声法所得混悬液粒径小于5μm颗粒占93%,大于10μm的只占0.3%。两种方法所得混悬液粒径分布有显著差异(P<0.01)。稳定性测试结果表明,涡旋法所得混悬液在6min内稳定可靠,超声法所得混悬液在15min内能均匀分散,此后取药需重新分散,且药物仍然均匀可用,颗粒度和放化纯度无明显变化。采用涡旋分散装置制备大颗粒混悬液时,操作简便,结果重现性良好,并同时避免了涡旋分散过程中因手动操作对人体造成的辐射损伤,减少了人为因素对颗粒度的影响。
Two different dispersing methods are used to prepare ^(188)Re-rhenium sulfide suspension, with obviously different particle-size distribution. Swirling device, offersus large-sized particles, 55% of which are larger than 5 μm, 19% are larger than 10 μm. However, ultrasonic dispersion can only produce suspension with large quantities of smaller particles, only 0.3% of which are larger than 10 μm and almost 93% are within 5 μm. The former suspension made by swirling device appears deposition within 6 minutes, and the other is not uniform after 15 minutes, which radiochemistry purity and particle-size distribution do not change distinctively within 24 hours. The conclusion is that both of the suspension should be regarded as radiopharmaceuticals for testing the optimal particle-size ranges for intra-articular injection.
出处
《同位素》
CAS
2004年第2期99-103,共5页
Journal of Isotopes
基金
中国科学院创新工程重大项目(KJCXI-SW-08)资助
