摘要
目的 :研究神经内分泌标记神经特异性的烯醇化酶 (NSE)、嗜铬粒蛋白 (CG)和突触素 (SYN)在功能性胰岛细胞瘤中的表达及意义。方法 :用链菌素亲生物蛋白 过氧化物酶法 (S P法 )对 2 1例功能性胰岛细胞瘤、3例胆管癌和癌旁组织石蜡标本进行了NSE、CG和SYN免疫组织化学研究。结果 :2 1例功能性胰岛细胞瘤中NSE、CG和SYN的阳性表达分别有 19、15和 18例 ,阳性率分别为 90 %、72 %和 85 % ;3例胆管癌和癌旁组织表达呈阴性。 2 1例功能性胰岛细胞瘤中 ,2 0例 3种标记物至少有 1种呈阳性表达。结论 :NSE、CG和SYN是功能胰岛细胞瘤的较特异的肿瘤标记物 ,联合检测有助于提高检测的敏感性。
Objective:To study the expression and clinical significance of neuron-specific enolase,chromogranin and synaptophysin in islet cell tumors.Methods:Twenty-one paraffin-embedded specimens with islet tumors and 3 cases cholangiocarcinoma and tissue nearby the tumor were recruited from Jan 1988 to Jun 2001.The S-P method was used for the detection of chromogranin,synaptophysin and neuron-specific enolase.Results:There were positive expressions of neuron-specific enolase,chromogranin and synaptophysin in 19,15 and 18 cases respectively,while negative results were observed in 3 cases of cholangiocarcinoma and the para-cancer tissue.Conclusion:CG,SYN and NSE may be specific tumor markers of islet cell tumors and combined detection can help to enhance the sensitivity.
出处
《中国现代普通外科进展》
CAS
2004年第3期147-149,共3页
Chinese Journal of Current Advances in General Surgery
