摘要
目的 研究恶性血液病患者血清叶酸 (FA)、维生素 B1 2 (VB1 2 )、血清铁蛋白 (SF)和促红细胞生成素(Epo)水平 ,以及骨髓铁染色和红系巨幼样变率 ,了解其与贫血的关系 ,为临床治疗提供依据。方法 选择 83例恶性血液病患者及 30例健康人血清标本 ,30例骨髓象大致正常骨髓涂片。用化学发光免疫法检测血清 FA、VB1 2 、SF水平 ,放射免疫法检测血清 Epo水平 ,对红系增生尚可的患者行骨髓涂片铁染色 ;同时观察骨髓红系巨幼样变率。结果 1初治、部分缓解 (PR)和血红蛋白 (Hb) <10 0 g/ L 患者的血清 Epo与 Hb呈负相关关系 ,血清FA、VB1 2 、SF与 Hb无相关关系。 2骨髓中红系巨幼样变率 PR明显高于初治和完全缓解 (CR)患者 ;红系巨幼样变率与 FA在 PR和初治患者存在相关关系 ,而 CR和 FA<2 .5 ng/ ml患者间无相关关系。 3骨髓红系百分比与Hb在初治患者存在正相关关系 ,与 Epo水平呈负相关关系。结论 恶性血液病患者贫血与 FA、VB1 2 、SF、Epo无关 。
Objective To study the relationship among FA,VB 12,SF,Epo and anemia in malignant hematologiic patients.Methods Collecting 83 malignant hemaologic patients and 30 healthy controls,serum folate acid,vitamin B 12 and ferritin were measured by chemiluminescence immunoassay.Levels of erythropoietin in serum were assayed by RIA-DA.Perls method was used to measure iron in-and-out cells.Erythriod megaloblastic ratio and erythriod percentage in bone marrow were observed.Results ①Erythropoietin was negative associated with Hb in initial diagnostic,partial remission(PR)and Hb<100g/L groups.Folate acid and ferritin were no significant association in any groups.②Erythroid megaloblastic ratio was notable higher in PR group than that of complete remission(CR)and initial diagnose and was positive associated with folate acid in pR group,but there were no relation in CR and FA<2.5ng/ml groups.③Erythriod percentage was positive related with Hb in initial diagnostic group,but negative correlation to erythropoietin.Conclusion There were no correlation between anemia in malignant hematonosis and folate acid,vitamin B 12 and ferritin.Anemia was not attributive to erythropoietin deficiency,but for bone marrow hematopoietic inhibition.
出处
《山东医药》
CAS
北大核心
2004年第16期8-10,共3页
Shandong Medical Journal
关键词
恶性血液病
贫血
FA
VB12
SF
EPO
Macignant hematonosis Folate acid Vitamin B 12 Ferritin Erythropoietin Anemia
