急性冠状动脉综合征患者外周血促红细胞生成素的变化及其临床意义被引量：3

The changes and clinical significance of peripheral blood erythropoietin in patients with acute coronary syndrome

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摘要目的探讨急性冠状动脉综合征(ACS)患者外周血促红细胞生成素(EPO)的水平及临床意义。方法采用酶联免疫吸附试验检测68例ACS患者[急性心肌梗死(AMI)35例、不稳定型心绞痛(UAP)33例]、28例稳定型心绞痛(SAP)和30名冠状动脉造影正常者(对照组)外周血血清EPO的水平。根据是否行支架植入术将ACS患者分为支架组(26例)和无支架组(42例)。结果 ACS组血清EPO水平为(1.21±0.27)mg/L,明显高于SAP组[(0.90±0.23)mg/L]和对照组[(0.81±0.36)mg/L](P均<0.01)。AMI组EPO水平显著高于UAP组和对照组(P均<0.05)。ACS支架组EPO水平明显高于非支架组(P<0.05)。结论 EPO水平与ACS密切相关,支架手术可导致外周血EPO水平增高。 Objective To study the level and its clinical significance of peripheral blood erythropoietin （EPO） in patients with acute coronary syndrome （ ACS ）. Methods The serum EPO levels were measured by enzyme-linked immunosorbent assay in 68 patients with ACS [35 patients with acute myocardial infarction （AMI） and 33 patients with unstable angina peetoris （UAP） 1,28 patients with stable angina pectoris （SAP） and 30 controls with normal coronary arteriograpby. The ACS patients were classified into intracoronary stent implantation group （26 cases ） and un-implantation group （42 cases）. Results The serum EPO level in ACS group [ （1.21 ± 0.27）mg/L] was significantly higher than that in SAP group [ （0.90 ± 0.23 ） mg/L ] and that in control group [ （ 0.81± 0.36 ） mg/L ] （ P 〈 0.01 ）. The serum EPO level in AMI group was higher than those in UAP group and control group（ P 〈 0.05 ）. The serum EPO level in implantation group was higher than that in un-implantation group （ P 〈 0.05 ）. Conclusions The serum EPO level is related with ACS. The serum EPO level will increase in ACS patients with intracoronary stent implantation.

作者宁莉魏殿军张敬伟

机构地区天津医科大学第二医院检验科

出处《检验医学》 CAS 2013年第4期280-282,286,共4页 Laboratory Medicine

关键词促红细胞生成素急性冠状动脉综合征冠状动脉疾病 Erythropoietin Acute coronary syndrome Coronary artery disease

分类号 R543.3 [医药卫生—心血管疾病]

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1曹优文.促红细胞生成素治疗慢性充血性心力衰竭临床研究[J].临床和实验医学杂志,2008,7(3):87-88. 被引量：4
2Wang GL,Semenza GL. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activityby hypoxia [ J ]. J Biol Chem,1993,268 ( 29 ) : 21513-21518.
3Bunn HF, Poyton RO. Oxygen sensing and molecularadaptation to hypoxia [ J ]. Physiol Rev, 1996,76 ( 3 ):839-885.
4Dunnett SB, Boulton AA, Baker GB. Neural transplan-tation methods [ M ]. Totowa : Humana Press, 1999 :385409.
5Al Falluji N, Lawrence-Nelson J, Kostis JB, et al. Effectof anemia on 1 -year mortality in patients with acutemyocardial infarction[ J]. Am Heart J,2002,144 (4 );636-641.
6Liang NL, Wei Y, Wu WC ,et al. Effects of verapamil onthe proliferation,DNA synthesis and migration of humanhepatoma cell line HepG2 [ J ]. Sichuan Da Xue XueBao Yi Xue Ban,2011,42(2) :227-230.
7Saraste A, Pulkki K, Kallajoki M, et al. Apoptosis inhuman acute myocardial infarction [ J ] . Circulation,1997,95(2) :320-323.
8Tramontano AF,Muniyappa R,Black AD , et al.Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway[J] . Biochem Biophys Res Commun,2003,308 ( 4 ):990-994.