摘要
目的 :采用环磷酰胺、秋水仙碱联合治疗急性脑梗死病人 ,观察神经功能改善情况 ,同时初步探讨其作用机理。方法 :32例病人随机分为两组 ,对照组 16人 ,给予一般治疗。治疗组 16人 ,给予环磷酰胺、秋水仙碱联合治疗。分别于治疗前、治疗后 7天、 14天、 1月、 2月、 3月进行改良爱丁堡 -斯堪的纳维亚量表、NIH量表进行神经功能评分以及日常生活活动能力评分。同时对病人进行治疗前后的SPECT检查、血清中IL - 1、IL -6、TNF检测以及白细胞粘附分子检测。结果 :1 治疗组 14天～ 3月神经功能缺损评分显著降低 ,日常生活能力显著提高。 2 治疗组SPECT显示脑缺血区血流量明显改善。 3 IL - 1血清中含量和白细胞粘附分子CD18表达的百分率显著降低。结论 :环磷酰胺、秋水仙碱联合治疗急性脑梗死病人 ,能显著减轻神经功能缺损 ,改善缺血区脑血流 ,提高预后。其作用可能与减少中性粒细胞、IL - 1的数量以及减少CD18的表达有关。
Objective:To investigate whether cyclphosphomide(Cy)plus colchicines(Col)could reduce neurological functional defects and improve the prognosis of acute cerebral infarction.Also the mechanism was preliminarily studied.Methods:Thirty-two patients were randomly divided into control group and trial group.The control group received routine therapy and the latter received Cy plus Col besides routine treatment.The neurological function defects were assessed with modified Edinberg-Scandinavian Stroke scale,ADL and NIH scale at pretreatment,day 7,14 and month 1,2,3 after stroke onset.SPECT of patients and the level of IL-1?IL-6?TNF and CD 18 int he patient's plasma were carried out at pretreatment and post-treatment.Results:1.Compared with those of control group,the decrease of neurological function defects scores on day 14,month 1?2 and 3 after stroke onset were more obvious.2.The regional cerebral blood flow on SPECT was increased in the trial group.3.The decrease of the plasma level of IL-1 and the CD 18 expression on granulates and monocytes in the trial was significant lower than that of the control group.Conclusion:Cy plus Col not only reduce the neurological function defects but also improve the ischemic regional cerebral blood flow and the prognosis in the acute cerebral infarct.
出处
《华西医学》
CAS
2004年第2期220-221,共2页
West China Medical Journal
