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小G蛋白Rho/Rock信号转导通路与疾病 被引量:14

Rho/Rock mediated pathway:signal transduction and pathophysiology
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摘要 Rho Rock信号通路介导多种平滑肌与非平滑肌功能异常的疾病 ,是近年的研究热点之一。它通过调节细胞内微丝骨架的聚合状态 ,参与多种细胞的生物学行为。在支气管哮喘、血管痉挛、器官纤维化和肿瘤的浸润转移中均发现Rho Rock信号转导通路的异常活化。该文对该信号通路的组成、活化。
作者 孙骅 陈荣华
出处 《国外医学(儿科学分册)》 2004年第3期162-164,共3页 Foreign Medical Sciences(Section of Pediatrics)
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  • 1Masszi A, Di Ciano C, Sirokmany G, et al. Central role for Rho in TGF-betalinduced alpha-smooth muscle actin expression during epithelial-mesenchymal transition[J].Am J Physiol Renal Physiol,2003,284(5): F911-F924.
  • 2Kataoka C,Egashira K, Inoue S,et al. Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by longterm blockade of nitric oxide synthesis in rats[J]. Hypertension, 2002,39(2):245-250.
  • 3Hocking DC, Sottile J, Langenbach KJ. Stimulation of integron-mediated cell contractility by fibronectin polymerization[J]. J Biol Chem, 2000 , 275(14):10673-10682.
  • 4Sato M, Tani E, Fujikawa H, et al. Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm [J]. Circ Res,2000,87(3): 195-200.
  • 5Wettschureck N, Offermanns S. Rho/ Rho-kinase mediated signaling in physiology and pathophysiology[R]. J Mol Med, 2002,80(10): 629-638.
  • 6Iizuka K, Shimizu Y, Tsukagoshi H, et al. Evaluation of Y-27632, a rhokinase inhibitor, as a bronchodilator in guinea pigs[J]. Eur Pharmacol, 2000,406(2):273-279.
  • 7Kitazono T, Ago T, Kamouchi M, et al. Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo[J]. J Hypertens, 2002, 20(5): 879-884.
  • 8Mukai Y, Shimokawa H, Matoba T, et al. Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension[J].FASEB J,2001, 15(6):1062-1064.
  • 9Tachibana E, Harada T, Shibuya M, et al. Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid haemorrhage[J].Acta Neurochir, 1999,141(1):13-19.
  • 10Shimizu Y, Dobashi K, Iizuka K, et al. Contribution of small GTPase Rho and its target protein Rock in a murine model of Iung fibrosis[J]. Am J Respir Crit Care Med,2001,163(1):210-217.

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