摘要
小RNA是一类长度约22-28个核苷酸的非编码小分子RNA，近年来发现其在转录后水平和翻译水平的基因调控过程中发挥重要作用。上皮-间质转化（epithelial-mesenchymal transition, EMT）是指上皮细胞通过特定程序转化为具有间质表型细胞的生物学过程，它在生理和病理过程中发挥了重要作用。近年来发现小RNA在各种器官纤维化的EMT过程中也起了重要作用。本文就小RNA在器官纤维化EMT过程中的作用作一综述，以期为器官纤维化疾病的治疗提供新的思路。
MicroRNA （miRNA） is a class of non-coding small molecule RNA with about 22 to 28 nucleotides. Recently, they are found to play an important role in gene regulation on post-transcriptional and translation level. Epithelial-mesenchymal transition （EMT） is a biological process that epithelial cells transform into cells with mesenchymal phenotype through a specific program, and it plays an important role in many physiological and pathological processes. It is discovered that miRNA also plays an important role in EMT process of various organ fibrosis in recent years. In this paper, the progress of research on the role of miRNA in the EMT process of organ fibrosis is reviewed to provide new ideas for the future treatment of organ fibrosis disease.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2013年第6期744-747,共4页
Fudan University Journal of Medical Sciences
基金
上海市自然科学基金项目(11ZR1405700)
上海市医学重点专科建设计划项目(ZK2012B20)~~
