摘要
目的设计合成白藜芦醇类似物 ,并测试其抗佛波酯 (TPA)促癌作用。方法以 3,5 二羟基苯甲酸为原料经多步反应合成目标化合物 ,采用TPA致小鼠耳肿胀促癌法确定目标化合物抗TPA促癌作用。结果所有合成的目标化合物通过1H NMR确认其结构 ,大部分化合物具有明显的抗TPA促癌作用。结论白藜芦醇及其类似物具有较强抗TPA促癌作用。
Objective To design and synthesize resveratrol and its analogs,and to assay their activity of preventing the cancer induced by TPA.Methods The target compounds were synthesized from 3,5-dihydroxybenzoic acid.The activity of preventing the cancer induced by TPA was tested.Result The structures of all the target compounds synthesized were confirmed by 1H-NMR.Most target compounds had potent activity of preventing the cancer induced by TPA.Conclusions Resveratrol and its analogs show good antipromotion activity of TPA.
出处
《沈阳药科大学学报》
CAS
CSCD
2004年第4期261-263,共3页
Journal of Shenyang Pharmaceutical University
基金
国家自然科学基金青年基金资助项目 (3980 0 185 )
关键词
制备
化学合成
白藜芦醇类似物
抗促癌
TPA
preparation
chemical synthesis
resveratrol analogs
antipromotion
TPA
