摘要
在大鼠损伤背根节神经元受到去甲肾上腺(NE)、四乙基胺(TEA)和高浓度钙等剌激的实验中,观察到非周期放电的神经元明显地比周期放电的神经元对外界刺激的反应敏感程度高。现有的结果表明许多非周期放电的神经元实际上表现为确定性的混沌运动,比如混沌尖峰放电、混沌簇放电以及整数倍放电等。以修正的胰腺β细胞Chay模型为例,通过对其分岔结构的分析和对构成混沌吸引子的基本骨架的不稳定周期轨道的计算,揭示了分岔、激变和混沌运动对参数敏感依赖性是该现象产生的动力学机制。同时指出以往使用平均发放率来刻划可兴奋性细胞放电活动存在的缺陷,提出了一种新的利用周期轨道信息的刻划方法。
It has been observed that aperioidic firing neurons have higher sensitivity than periodic firing ones in the experiments about the injured dorsal root ganglion neurons in rats subjected to norepinephrine (NE), tetraethylammonium (TEA), high Ca2+ solutions, et al. Existing results show that a number of apeirodic firing neurons actually exhibit deterministic chaotic motions, for example, chaotic spiking, chaotic bursting, integer multiple spiking, and so on. Bifurcations, crises and sensitive dependence of chaotic motions on parameters are considered as the dynamic mechanisms for the phenomena of sensitive response through the analysis of the bifurcation structure and the calculation of unstable periodic orbits constituting the most fundamental building blocks of a chaotic attractor in terms of the modified pancreatic he information of periodic orbits.
出处
《生物物理学报》
CAS
CSCD
北大核心
2004年第3期209-216,共8页
Acta Biophysica Sinica
基金
国家自然科学基金重点项目(30030040)
国家自然科学基金面上项目(10172067)
