2Friedman.The alphabet of weight control [J].Nature,1997, 385:119-120.
3He Y, Chen H, Quon M J, et al.The mouse obese gene [J].J Biol Chem, 1995, 270: 27728-27733.
4Tartaglia L A, Dembski M, Weng X, et al.Identification and expression cloning of leptin receptor, OB-R [J].Cell,1995, 83:1263-1271.
5Flier J S.Clinical review 94:What's it a name? In search of leptin's physiologic role [J].Clini Endocrinol and Metabol, 1998,83:1407-1413.
6Houseknecht K L, Baile C A,Matteri, R L,et al.The biology of leptin: a review[J].J Anim Sci, 1998,76:1405-1420.
7Barash I A,Cheung C C, Weigle D S, et al.Leptin is a metabolic signal to the reproductive system [J].Endocrinology, 1996,137:3144-3151.
8Chehab F F, Mounzih K, Lu R,et al.Early onset of reproductive function in normal female mice treated with leptin[J]. Science (Wash D C), 1997,275: 88-90.
9Hummel K P, Dickie M M, Coleman D L.Diabetes, a new mutation in the mouse [J].Science (Wash D C),1966,153:1127-1128.
10Zhang Y Y ,Proenca R,Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue [J].Nature, 1994,372:425-432.
二级参考文献50
1[1]Ahima R S et al. 1996. Role of leptin in the neuroendocrine response to fasting[J]. Nature, 382:250～252.
2[2]Bjorbaek C, Uotani S,da Silva B, Flier J S. 1997. Divergent signaling capacities of the long and short isoforms of the leptin receptor [ J ]. J Biol. Chem., 272: 32686～32695.
3[3]Borstein S R et al. 1997. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland. Leptin inhibits cortisol release directly[J]. Diabetes, 46: 1235～1238.
4[4]Campfield L A et al. 1995. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks [ J ]. Science ( Wash DC), 269: 546 ～549.
5[5]Carro J F et al. 1997. Regulation of in vivo growth hormone secretion by leptin[J ]. Endocrinology, 138:2203～2206.
6[6]Chehab F F et al. 1997. Early inset of reproductive function in normal female mice treated with leptin[J]. Science, 275:88～90.
7[7]Cohen S L et al. 1996. Characterization of endogenous human leptin[J ]. Nature, 382:589.
8[8]Coleman D L. 1978. Obese and Diabetes: two mutant genes causing diabetes- obesity syndromes in mice[J].Diabetologia,14: 141～148.
9[9]Coleman D L. 1973. Effects of parabiosis of obese with diabetes and normal mice [J ]. Diabetologia, 9:294～298.
10[10]Cusin I et al. 1995. The ob gene and insulin A relationship leading to clues to the understanding of obesity[J ]. Diabetes, 44: 1467～1470.
4SASAKI S,CLUTFER A C,POMP D.Assignment of the porcine obese (leptin)gene to chromosome 18 by linkage analysis of a new PCR-based polymorphism [J].Mamm Genome, 1996,7(6) :471-472.
5GHILARDI N ,SKODA R C.The leptin receptor activates janus kinase 2 and signals for proiferation in a factor-dependent cell line[J ].Mol Endocrinol, 1997,11 (4) :393-399.
6BANKS A S,DAVIS S M,BATES S H,et al.Activation of downstream signals by the long form of the lcptin receptor [J ].J Biol Chem, 2000,275 (19) : 14563-14572.
7MORTON G J,CYNNUBGS D E,BASKIN D G,et al.Central nervous system control of food intake and body weight [J]. Nature, 2006,443 (7109 ) : 289-295.
8BATES S H, MYERS Jr M G.The role of leptin receptor signaling in feeding and neuroendocrine function [J].Trends Endocrinol Metab, 2003,14(10) :447-452.
9MORRISON C D,MORTON G J,NISWENDER K D,et al. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH- kinase signaling [J ].Am J Physiol Endocrinol Metab, 2005, 289: 1051-1057.
10YU YING-HUA, DENG CHAO,HUANG XU-FENG.Obese reversal by a chronic energy restricted diet leaves an increased Arc NPY/AgRP, but no alteration in POMC/ CART,mRNA expression in diet-induced obese mice [J]. Behavioural Brain Research, 2009,205 ( 1 ) : 50-56.
