摘要
目的 探讨微量元素在肺癌组织、癌旁组织及良性肺组织中的浓度及其变化规律。方法 利用原子吸收光谱法 (atomicabsorptionspectrometry ,AAS)对 19例肺癌患者的肺癌组织和癌旁组织、9例肺部良性疾病患者的肺组织中的镉 (cadmium ,Cd)、铅 (lead ,Pb)、铬 (chromium ,Cr)、锰 (manganese ,Mn)、镍 (nickel,Ni)、铜 (cuprum ,Cu)、锌 (zinc ,Zn)等七种元素进行了含量分析 ,采用同一元素在癌组织与癌旁组织的浓度比值判断此元素在肺癌发生、发展中的意义。结果 癌组织中Cu、Pb含量高于癌旁组织 ,癌旁组织又高于正常组织 ;癌旁组织中Cd、Cr、Mn、Ni、Zn含量高于肺癌组织 ;Pb元素主要积聚在肺癌组织 ;Ni元素主要积聚在癌旁组织。结论 不同肺组织中微量元素的含量存在差异 ,表明微量元素含量的变化与肺癌发生、发展有一定的关系。
Objective To investigate the contents of trace elements in benign lung tissue, lung cancer tissue and paracancerous tissue of patients with lung cancer and their rule of variation. Methods Atomic absorption spectrometry was used to measure the contents of cadmium (Cd), lead (Pb), chromium (Cr), manganese (Mn), nickel (Ni), cuprum (Cu) and zinc (Zn) in lung cancer tissues and paracancerous tissues from 19 lung cancer patients and 9 patients with benign pulmonary diseases. The ratio of a certain element’s content in cancer tissues and paracancerous tissues was applied to evaluate the role of the element in tumor generation and development. Results The contents of Cu, Pb in cancer tissues were higher than those in paracancerous tissues, and the contents in paracancerous tissues were higher than those in benign tissues; The contents of Cd, Cr, Mn, Ni and Zn were in cancer tissues than those in paracancerous tissues. Pb showed significant accumulation in cancer tissues, while Ni showed significant accumulation in paracancerous tissues. Conclusion Significant differences of the contents of trace elements are found among the different lung tissues, and this result indicates that the change of trace elements’ contents is related to the generation and development of lung cancer.
出处
《中国肺癌杂志》
CAS
2004年第3期222-225,共4页
Chinese Journal of Lung Cancer
关键词
肺肿瘤
微量元素
原子吸收
Lung neoplasms Trace elements Atomic absorption
