摘要
目的 :探讨充血性心力衰竭 (CHF)患者血浆脑钠素 (BNP)浓度变化与心功能和 30 d再住院率的关系。方法 :随机选择 CHF患者 78例进行心功能分级 (NYHA分级 ) ,并测定其入院及出院当天血浆 BNP浓度 ,选择 2 0例健康中老年健康体检者作为对照组。结果 :CHF组较对照组血浆 BNP浓度明显升高 ,4 77± 2 4 4 pmol/ L 对 184± 5 4pmol/ L(P<0 .0 1) ;不同心功能分级之间均有显著差异 ,NYHA ～ 级血浆 BNP浓度分别为 2 6 3± 5 6、4 12±16 4、770± 14 2 pm ol/ L(各组间 P<0 .0 1)。 CHF患者 33例出院时血浆 BNP浓度小于 30 0 pmol/ L,30 d再住院率6 % ;4 5例出院时血浆 BNP浓度大于 30 0 pmol/ L,30 d再住院率 2 7% (P<0 .0 5 )。结论 :血浆 BNP浓度可作为诊断CHF的参考指标 ,随着心衰的加重 ,血浆 BNP浓度逐渐升高 ,当血浆 BNP浓度降至 30 0 pmol/ L 以下时 ,患者 30 d再住院率显著下降。
AIM: To discuss the relations of the concentration of plasma brain natriuretic peptide(BNP) with the severity of congestive heart failure and the rate of 30-day re-admission. METHODS: Plasma BNP concentrations of congestive heart failure were measured immediately after admission and before discharge. The BNP concentrations of the normal controls were measured immediately as examination only. RESULTS: The Plasma BNP concentrations of congestive heart failure were significantly higher than those of the normal controls (477±244 pmol/L vs 184±54 pmol/L, P<0.01), and that they also increased according to the severity of congestive heart failure (P<0.01). The Plasma BNP concentrations of 33 cases of CHF group were under 300 pmol/L, and those of 45 cases were over 300 pmol/L at discharging. The rate of 30-day re-admission was 6% and 27% respectively (P<0.05). CONCLUSION: The Plasma BNP concentrations, which increase according to the severity of CHF,may be an index for diagnosing CHF. The rate of 30-day re-admission is significantly lower if the plasma BNP concentrations are under 300 pmol/L at discharging.
出处
《心脏杂志》
CAS
2004年第3期266-267,共2页
Chinese Heart Journal
关键词
心力衰竭
充血性
脑钠素
heart failure, congestive
brain natriuretic peptide
