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Utrophin基因与Utrophin蛋白的研究进展 被引量：2

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摘要 Utrophin基因位于6q24,长1Mb,cDNA全长约为13kb,包含73个外显子,是继Dystrophin之后人类发现的第二个大基因。Utrophin蛋白与Dystrophin有广泛的同源性,相对分子质量为395000Da,在一些肌病和胚胎发育期位于肌细胞膜下,出生后则局限在神经肌肉接头和肌腱接头。定位于神经肌肉接合处(neuromuscular junction,NMJ)肌纤维膜上的Utrophin蛋白将细胞外间质与细胞膜下骨架蛋白连接起来,发挥细胞跨膜信号转导的重要作用。从新的角度探讨其功能,可望为阻断肿瘤侵袭转移开辟一个新途径。
作者 杨兆颖 李钰 李璞
机构地区 哈尔滨医科大学遗传学与细胞生物学教研室
出处 《国外医学（遗传学分册）》 CAS 2004年第3期133-136,180,共5页 Foreign Medical Sciences(Section of Genetics )
基金 国家自然科学基金资助项目(No.30170516) 国家自然科学基金国际合作项目(No.30213023) 黑龙江省教育厅海外学人资助项目(1054HZ013)
关键词 Utrophin基因 Utrophin蛋白 研究进展 肌病 胚胎发育期 细胞膜骨架蛋白 细胞跨膜信号转导
分类号 Q51 [生物学—生物化学]
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参考文献24

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同被引文献27

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  • 10Pozzoli U, Sironi M, Cagliani R, et al. Comparative analysis of the hu- man dystrophin and utrophin gene structures [ J ]. Genetics, 2002,160 (2) :793 -798.

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国外医学（遗传学分册）
2004年 第3期

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