摘要
以价格低廉的 3-氯 - 4 -氟苯胺为起始原料,合成普卢利沙星的关键中间体 7-氯 - 6 -氟 - 4 -羟基苯并[h]吡啶- 3-甲酸乙酯获得成功。此法成本低,收率高。
chloro-4-fluorophenylamine was used as the cheap material for the synthesis of 7-chloro-6-fluoro-4-hydroxy-phenyl [h] pyridine-3-ethyl formate , the intermediate of Prulifloxacin . This new method is meaningful for the synthesis of Prulifloxacin for lower cost and good yield .
出处
《齐鲁药事》
2004年第2期50-51,共2页
qilu pharmaceutical affairs
