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以PPAR为靶点的抗糖尿病药物研究 被引量：6

Advances in Antidiabetic Agents Targeted PPAR
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摘要 Ⅱ型糖尿病是以胰岛素耐受、高血糖、高血脂为主要特征的一种代谢性疾病 ,而过氧化酶增殖体激活受体 (PPAR)是配体激活转录因子 ,属于核受体基因家族 ,在调节血糖、胰岛素敏感性、脂肪贮存与代谢等方面起着至关重要的作用。近年来突破传统治疗药物的基本结构 ,研制开发以PPAR为靶点的新型抗糖尿病药物已成为药物研究的一大热点。分类综述不同结构的PPAR激动剂用于糖尿病治疗的研究进展。 Type 2 diabetes is a metabolic disease characterized by insulin resistance, hyperglycemia, and hyperlipidemia. Peroxisome proliferator-activated receptors (PPARs), a family of transcription factors, play a crucial role in regulating glycemia,insulin sensitivity and the storage and catabolism of dietary fats. Recently, different from the traditional drugs for the treatment of diabetes, a class of novel antidiabetic agents targeted PPAR as treatment of diabetes and its complication has been a hotspot of drug research. The advances in this field were reviewed.
作者 黄莺 张惠斌 周金培 黄文龙
机构地区 中国药科大学新药研究中心
出处 《药学进展》 CAS 2004年第5期193-198,共6页 Progress in Pharmaceutical Sciences
基金 国家高科技研究发展计划 (86 3计划 )资助项目(2 0 0 3AA2Z35 30 )
关键词 过氧化酶增殖体激活受体 糖尿病 抗糖尿病药物 靶点 药物研究 Diabetes,PPAR,Thiazolidinediones
分类号 R977.15 [医药卫生—药品]
  • 相关文献

参考文献16

  • 1Tenenbaum A, Fisman E Z, Motro M.Metabolic syndrome and type 2 diabetes mellitus: focus on peroxisome proliferator activated receptors (PPAR) [J]. Cardiovasc Diabetol,2003,2(1):1-7.
  • 2黄文龙 张惠斌.过氧化酶增殖体激活受体(PPARS)及其药物研究进展[A].彭司勋.药物化学进展(2)[M](第三卷)[C].北京:北京化学工业出版社,2003.233-352.
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同被引文献30

  • 1周辛波,林翠芳,李松.新型抗糖尿病药GW409544的合成工艺改进[J].中国药物化学杂志,2005,15(3):167-169. 被引量：2
  • 2黄锁义,王麟生,田华.L-3-氟-酪氨酸的合成研究[J].化工技术与开发,2005,34(5):1-3. 被引量：1
  • 3卢翠芬,杨桂春,陈祖兴.L-酪氨酸合成手性噁唑烷酮的研究[J].湖北大学学报（自然科学版）,2005,27(4):366-368. 被引量：4
  • 4Hiroshi O,Hiroki U,Akira M,et al..Preparation and purification of hypoglycemic and hypolipemic 5-[6-(2-fluorobenzyloxy)-2-naphthyl] methyl-2,4-thiazolidinedione[J].JP,2003,2:13.
  • 5Lee JY,Park WH,Cho MK,et al..Design and synthesis of novel antidiabetic agents[J].Arch Pham Res,2005,28(2):142.
  • 6Jeon R,Park SY.Synthesis and biological activity of benzoxazole containing thiazolidinedione derivatives[J].Arch Pharm Res,2004,27(11):1 099.
  • 7Cantaeuzene K L, Kirk D H, Mcculloh C R. Effect of fluorine subseitution on the agonist specificity of norepinephrine[J]. Science, 1979, 204 ( 4398 ) : 1217 - 1219.
  • 8Oplinger J A. Disdonery of petent PPARAlpha and PPARgamms dual agonist [ C]. 21STACS Natl Meet, 2001 ,Abst MEDI:238.
  • 9Sorbera L A, Leeson P A, Martin L, et al. Farglitazar [ J]. Drugs Fut,2001,26(4) :354 - 363.
  • 10Faita G, Paio A, Quadrelli P, et al. Solid supported chiral auciliaries in asymmetric synthesis(Part 2) ;Catalysis of 1,3-dipolar eyeloadditions by Mg( Ⅱ ) cation [J]. Tetrahedron,2001,57(39) :8313 -8322.

引证文献6

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药学进展
2004年 第5期

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