摘要
以L-酪氨酸为原料,经由羧基、氨基保护后,在其苯环上3-位直接硝化,硝化后的产物在铁粉和醋酸的作用下还原成3-位氨基的衍生物,再重氮化、光照下发生氟代反应,最后,氟代完成后的产物盐酸水解除去保护基后,即得到光学纯的L-3-氟-酪氨酸。经熔点、旋光度、1H-NM R及M S检测,结果与文献值一致。本文方法是合成L-3-氟-酪氨酸的理想方法。
The carboxyl and amino group of L-tyrosine were protected respectively,and 3-position of aromatic ring of L-3-F-tyrosine was nitrated. The nitro group of the product was reduced to amino group by iron and acetic acid,and then diazotized and fluorinated under irradiation. Thus the protected L-3-F-tyrosine was formed. After hydrolyzed with hydrochloric acid, optically pure L-3-F-tyrosine was obtained. Determined by melting point, optical rotation, ^1H-NMR and MS, the results were accord with the literature.
出处
《化工技术与开发》
CAS
2005年第5期1-3,共3页
Technology & Development of Chemical Industry
基金
国家教育部高等学校访问学者基金资助项目(高校访问学者基金[200209])
广西壮族自治区教育厅课题(桂教科研[2003]22号)
关键词
L-3-氟-酪氨酸
羧基保护
氨基保护
硝化
还原
氟代
水解
L-3-F-tyrosine
carboxyl group protected
amino group protected
nitration
reduction
fluori- nation
hydrolysis
