摘要
目的 :探讨NF κBp6 5阳性率、可溶性细胞间黏附分子 1 (sICAM 1 ) ,C 反应蛋白 (CRP)浓度与冠心病不同类型斑块稳定性的关系。方法 :采用夹心酶联免疫吸附法测定血浆sICAM 1和C 反应蛋白浓度 ;免疫组化染色测定外周血单核细胞NF κBp6 5阳性率。结果 :NF κBp6 5阳性率和sICAM 1浓度水平在基线急性心肌梗死(AMI)组和不稳定性心绞痛 (UAP)组明显高于稳定性心绞痛 (SA)组和对照组 (P <0 .0 1 ) ,3个月后复查与基线比较差异无统计学意义 (P >0 .0 5 ) ;血浆CRP浓度在基线AMI组和UAP组明显高于SA组和对照组 (P <0 .0 1 ) ,3个月后复查CRP浓度明显降低 (P <0 .0 1 )。结论 :NF κBp6 5阳性率和sICAM 1 ,C 反应蛋白浓度与冠心病不同类型斑块稳定性有关。
Objective To study the relationship between levels of activity of NF κB p65,plasma soluble inter cellular adhesion molecule 1,C reactive protein on plaque stability,and different types of coronary heart disease. Methods We measured the levels of plasma soluble inter cellular adhesion molecule 1 and C reactive protein by enzyme linked immunosorbant assay and the activity of NF κB p65 in peripheral blood lymocytes immunohistochemically.Results Compared with the stable angina and the control group, the baseline activity of NF κB p65, sICAM 1 and C reactive protein was significantly elevated in the acute myocardial infarction and the unstable angina ( P <0.01).After 3 month follow up,the levels of activity of NF κB p65 and sICAM 1 were unchanged ( P >0.05) .In all groups,C reactive proteins were lowered at the review ( P <0.01). Conclusion The levels of activity of NF κB p65, sICAM 1 and C reactive protein are related to the plaque stability among different types of coronary heart disease. NF κB p65, and sICAM 1 are not affected by the acute event .These plasma markers may be important risk factors for the development of the acute coronary syndrome.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2004年第2期227-229,共3页
Journal of Central South University ：Medical Science
基金
湖南省重点学科建设科研基金 (2 50 1 71 0 0 2 )
