摘要
AIM: To explore the effect of Hejie decoction (HJD) (mediation decoction) on T cellular immune state of chronic hepatitis B patients.METHODS: Sixty-five patients with chronic hepatitis B were randomly divided into 2 groups. Forty patients in the treatment group were treated by HJD, and 25 patients in the control group were treated by routine Western medicine. The TCRVβ7 gene expression, T lymphocyte subsets (CD3^+, CD4^+, CD8^+,CD4^+/CD8^+) levels were observed before and after treatment.RESULTS: The level of CD4^+ cells was lower whereas the level of CD8^+ cells was higher in patients than in the normal group. There was no significant difference between the levels of CD3^+ cells in patients and normal persons. After 6 months of treatment, ALT, AST, TB levels of the 2 groups were obviously decreased, and the level of CD4^+ cells was increased whereas the level of CD8^+ cells was decreased in the treatment group. However, the level of CD4^+ cells and CD8^+ cells had no significant difference in the control group. TCRVβ7 expressions were detected in 6 patients of the treatment group, whose HBV-DNA and HBeAg turned negative and ALT became normal. HBeAg in another 3 patients turned negative while HBV-DNA did not, and TCRVβ7 expressions were not detectable. TCRVβ7 expression could not be detected in the control group, HBV-DNA of the control group did not turn negative. HBeAg in 1 patient turned negative while HBV-DNA did not, and TCRVβ7 expressions were not detectable. The total effective rate was not significantly different between the 2 groups and the markedly effective rate was significantly different(P<0.01).CONCLUSION: H3D is effective for treating chronic hepatitis B, and its effect seems to relate with the improvement of the TCRVβ7 expression of chronic hepatitis B patients, thus activating T cells and eliminating HBV. T cellular immune function plays an important role in HBV infection and virus elimination.
AIM: To explore the effect of Hejie decoction (HJD) (mediation decoction) on T cellular immune state of chronic hepatitis B patients. METHODS: Sixty-five patients with chronic hepatitis B were randomly divided into 2 groups.Forty patients in the treatment group were treated by HJD,and 25 patients in the control group were treated by routine Western medicine.The TCRVβ_7 gene expression,T lymphocyte subsets (CD_3^+,CD_4^+,CD_8^+, CD_4^+/CD_8^+) levels were observed before and after treatment. RESULTS: The level of CD_4^+ cells was lower whereas the level of CD_8^+ cells was higher in patients than in the normal group.There was no significant difference between the levels of CD_3^+ cells in patients and normal persons.After 6 months of treatment,ALT,AST,TB levels of the 2 groups were obviously decreased,and the level of CD_4^+ cells was increased whereas the level of CD_8^+ cells was decreased in the treatment group.However,the level of CD_4^+ cells and CD_8^+ cells had no significant difference in the control group.TCRVβ_7 expressions were detected in 6 patients of the treatment group,whose HBV-DNA and HBeAg turned negative and ALT became normal.HBeAg in another 3 patients turned negative while HBV-DNA did not,and TCRVβ_7 expressions were not detectable.TCRVβ_7 expression could not be detected in the control group,HBV-DNA of the control group did not turn negative.HBeAg in 1 patient turned negative while HBV-DNA did not,and TCRVβ_7 expressions were not detectable.The total effective rate was not significantly different between the 2 groups and the markedly effective rate was significantly different (P<0.01). CONCLUSION: HJD is effective for treating chronic hepatitis B,and its effect seems to relate with the improvement of the TCRVβ_7 expression of chronic hepatitis B patients,thus activating T cells and eliminating HBV.T cellular immune function plays an important role in HBV infection and virus elimination.
基金
Supported by Guangdong Administrative Bureau of TCM and Chinese Drugs,No.98374 and No.100108
