摘要
目的 检测成人先天性心脏病肺动脉高压患者血清中胶原前体 (PC)Ⅰ、Ⅲ的变化 ,研究其是否能够反应肺血管病变的程度。方法 选择本院心胸外科2003年1～6月左向右分流先心患者40例 ,其中室间隔缺损18例 ,房间隔缺损15例 ,动脉导管未闭5例 ,其他2例。术前心超测肺动脉压力30～40mmHg17例 ,41～50mmHg18例 ,>50mmHg5例。对照组健康成人40例。放免法测定各组血清PCI及PCⅢ含量 ,并与肺动脉压力作相关分析。结果 实验组PCⅠ、PCⅢ含量均明显高于对照组 (P均<0.05) ,实验组PCⅠ含量与肺动脉压力成正相关 (r=0.865,P=0.035)。 结论 血清学检测PCⅠ与PCⅢ可在一定程度上反映肺血管病变的程度。
Objective To detect changes of serumprecollagen(PC)ⅠandⅢin patients with congenital heart disease associated with pulmonary hypertension and to study the correlation between themand the degree of the pathological change of pulmonary artery. Methods 40patients with congenital heart disease associated with pulmonary hypertension were chosen,including18ventricular septal defect,15arterial septal defect,5patent arterial duct and other in2cases.Pulmonary artery pressure were detected by heart ultrasound before operation and pulmonary artery pressure in17cases between30to40mmHg,in18cases between41to50mmHg and in5cases over50mmHg.In the controlgroup,40healthy adults were chosen.Serum PCⅠandⅢwere measured by radioimmunoassay. Results The levels of serum PCⅠandⅢin patients were significantly higher than those in control group(P<0.05),The levels of PCⅠwere correlated positively with the pulmonary artery pressure(r=0.865,P=0.035). Conclusion The levels of serum PC I andⅢin patients with congenital heart disease associated with pulmonary hypertension can be used to reflect the pathological degree of pulmonary artery.
出处
《浙江临床医学》
2004年第5期354-355,共2页
Zhejiang Clinical Medical Journal
