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组织因子途径抑制物-1与临床疾病的相关性研究 被引量：5

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摘要 组织因子途径抑制物-1(TFPI-1)作为一种天然的抗凝物质,已受到越来越多的重视,其来源、结构、基因组成及其表达调控机制已基本明确。研究表明TFPI-1除了抑制凝血的功能外,还有促进血小板聚集、调节细胞增值和迁移等作用。一些血栓性疾病、感染性疾病、恶性肿瘤等患者血浆中TFPI-1的水平均有明显升高,研究TFPI-1与这些疾病的相关性具有重要的临床意义。
作者 刘伟 朱广瑾
机构地区 中国医学科学院中国协和医科大学基础医学院病理生理学系
出处 《国外医学（输血及血液学分册）》 2004年第3期216-219,共4页 Foreign Medical Sciences(Section of Blood Transfusion and Heanatology)
关键词 组织因子途径抑制物-1 临床疾病 相关性 抗凝物质 内皮细胞
分类号 R363 [医药卫生—病理学]
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参考文献25

  • 1Mousa SA, Bozarth J, Barrett JS. Pharmacodynamic properties of the low molecular weight heparin, tinzaparin: effect of molecular weight distribution on plasma tissue factor pathway inhibitor in healthy human subjects. J Clin Pharmacol, 2003,43(7):727-734.
  • 2Moatti D,Haidar B,Fumeron F,et al. A new T-287C polymorphism in the 5' regulatory region of the tissue factor pathway inhibitor gene. Association study of the T-287C and C-399T polymorphisms with coronary artery disease and plasma TFPI levels. Thromb Haem
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  • 4Gando S,Nanzaki S,Morimoto Y,et al. Tissue factor pathway inhibitor response does not correlate with tissue factor-induced disseminated intravascular coagulation and multiple organ dysfunction syndrome in trauma patients. Crit Care Med, 2001,29(2):262-266
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国外医学（输血及血液学分册）
2004年 第3期

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