摘要
目的探讨131I治疗甲状腺功能亢进(甲亢)的合理剂量及影响治疗效果的因素。方法对1 000例131I治疗甲亢患者的1～3年(1999～2002年)的随访资料进行统计学处理,对治愈患者的使用剂量及其影响因素之间的关系应用SPSS 10.0 软件进行分类偏相关分析,计算剂量与其影响因素间的相互关系。结果治疗剂量与甲状腺大小、硬度、肿大类型关系极为密切,其次与年龄、病史长短、甲状腺吸131I率、峰值前移有一定关系。结论在使用131I治疗甲亢时,使用剂量不仅要考虑甲状腺大小及吸收剂量,还要考虑到甲状腺硬度、有无结节,其次还要考虑年龄、病史长短等因素,因人而异,确定治疗剂量,尽量避免甲状腺功能低下(甲低)出现,达到最佳治疗效果。
Objective To probe into optimal delivered dose of 131I therapy in hyperthyroidism and factors of effecting outcome. Methods Data of 1 000 patients with hyperthyroidism, receiving 131I therapy in our department and followed up during 1～3 years (from 1999 to 2002) were analyzed using statistics method. Partial correlations analysis was performed between delivered doses and other variables effecting outcome among cured patients using SPSS10.0 for windows, partial correlations coefficients and P values were calculated. Results Close relationship was found between doses and volume(mass),rigidity and type of goiter. There was weak relationship between doses and age, term of history, 24 hour 131I uptake rate and peak value forward shift. Conclusions Dose delivered of 131I therapy in hyperthyroidism depend not only upon volume of goiter, but also upon rigidity and type of goiter. Still considering other factors such as age, 24 hour thyroid 131I uptake, course of disease and so on need to be considered. Thus, it is capable of decreasing frequence of hypothyroidism and reaching optimal therapy outcome. How to determine delivered dose in practice? We will study further.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2004年第3期248-250,共3页
Chinese Jouranl of Endemiology
