摘要
目的 :观察中药白松片的抗抑郁作用。方法 :采用慢性综合应激法建立抑郁大鼠模型。观察白松片对该型大鼠行为学改变的影响。结果 :与空白组相比 ,模型组大鼠的水平穿越格数、竖立次数、理毛时间均减少 ,中央格停留时间、粪便粒数均增加 ;大鼠体重增长数明显减少 ;蔗糖溶液消耗量明显减少 (P <0 .0 5～ 0 .0 1)。与模型组相比 ,白松片组大鼠的水平穿越格数、竖立次数、理毛时间均有增加 ,中央格停留时间、粪便粒数均有减少 ;大鼠体重增长数增加 ;蔗糖溶液消耗量增加 (P <0 .0 5～ 0 .0 1)。结论 :白松片能明显改善抑郁动物的各项行为学指标 。
Objective: To observe the antidepressant effect of Baisong tablet. Methods: The depression model of rats was established by chronic unpredictable mild and comprehensive stress. The effects of Baisong tablet on their behavioral changes was observed. Results: Compaired to normal group, the crossed squares, number of rearing, time of decorating, the increase of body weight and the sucrose solution intake were decreased significantly, and the staying time in central square and defecation were increased in depression model group(P<0.05, or P<0.01). Compaired to the depression model group, the crossed squares, number of rearing, time of decorating were increased, and the staying time in central square and defecation were decreased(P<0.05, or P<0.01). The increase of body weight and sucrose solution intake were also increased significantly in Baisong tablet group. Conclusion: Baisong tablet can improve behavior of depression model rats and possess an antidepressant effect.
出处
《山东中医药大学学报》
2004年第3期231-233,共3页
Journal of Shandong University of Traditional Chinese Medicine
基金
国家"十五"科技攻关项目资助课题 ( 2 0 0 1BA70 1A2 2 )
关键词
白松片
慢性应激
抑郁模型
抗抑郁
大鼠
BAISONG tablet
chronic stress
depression model
behavior
