摘要
目的 考察注射用己酮可可碱冻干粉末分别与 5 %葡萄糖注射液和 0 .9%氯化钠注射液配伍的稳定性及溶血性。方法 采用高效液相色谱法及溶血试验。结果 在强光 4 5 0 0lx± 5 0 0lx、4 0℃± 2℃条件下 2 4h内 ,主药含量和降解产物均无明显变化。注射用己酮可可碱冻干粉末分别与 2种输液配伍后无溶血现象和凝集现象。结论 注射用己酮可可碱冻干粉末与2种输液配伍 2 4h内稳定 ,临床上可配伍使用。
Objective To study the stability and hemolysis on the compatibility of pentoxifylline (Freeeze drying sterile injection powder) with 5% glucose injection and 0.9% sodium chloride injection .Methods HPLC and hemolytic test . Results pentoxifylline mixed in infusion fluid with 5% glucose injection and with 0.9% sodium chloride injection were stable under light 4500lx±500 lx and at 40 ℃±2 ℃ for 24 h and were not hemolysis and agglomeration . Conclusion pentoxifylline with 5% glucose injection and with 0.9% sodium chloride injection are compatible for injection in 24 h.
出处
《广东药学》
2004年第2期25-28,共4页
Guangdong Pharmaceutical Journal
