摘要
目的考察注射用亚硫酸氢钠穿心莲内酯分别与5%葡萄糖注射液和0.9%氯化钠注射液配伍的稳定性及溶血性。方法采用高效液相色谱法试验。结果亚硫酸氢钠穿心莲内酯分别与5%葡萄糖注射液和0.9%氯化钠注射液配伍后,在强光(4 500±500)Lx、(40±2)℃两种条件下,24 h内,主药含量和降解产物均无明显变化。注射用亚硫酸氢钠穿心莲内酯分别与2种输液配伍后无溶血现象和凝集现象。结论亚硫酸氢钠穿心莲内酯与2种输液配伍24 h内稳定,临床上可配伍使用。
Objective To study the stability and hemolysis of andrographolide-sodium bisulfite injection mixed with 5% glucose and 0. 9% sodium chloride injections. Methods and Results HPLC was used to evaluate the chemical stability of the admixtures. Andrographolide-sodium bisulfite injection＇mixed with 5% glucose and 0.9% sodium chloride injections was stable when exposed to light radiation （4 500 ±500 ） Lx at （40 ± 2 ）℃ for 24 h, and no hemolysis was measured throughout the trial. Conclusion Andrographolide-sodium bisulfite injection mixed with 5% glucose and 0.9% sodium chloride injections is stable for 24 h.
出处
《广东药学院学报》
CAS
2006年第1期68-70,共3页
Academic Journal of Guangdong College of Pharmacy
