摘要
目的 探讨无症状性脑梗死 (ACI)患者智能障碍及事件相关电位 (ERP)的特点。 方法 用修订的韦氏成人智力量表 (WAIS RC)及体感刺激诱发的事件相关电位检测 5 3例ACI患者和5 0名健康人 ,分别测得语言智商 (VIQ)、操作智商 (PIQ)、总智商 (FIQ)和ERP各波的潜伏期及P30 0波幅。并将 5 3例ACI患者分为单发腔隙性脑梗死组 (30例 )和多发腔隙性脑梗死组 (2 3例 )进一步分析。 结果 4 9 1%～ 5 8 5 %的ACI患者有不同程度的智能障碍 ,WAIS RC各项测验得分在ACI组均显著低于健康组 (均为P <0 0 1) ;多发腔隙性脑梗死组智能障碍较单发腔隙性梗死组重 (P <0 0 1) ,各项测验得分在多发腔隙性脑梗死组均明显低于单发腔隙性梗死组 (P <0 0 0 1～ 0 0 5 ) ,表现为皮质下痴呆的特征 ;ACI患者反映认知功能的识别波如N2 、P30 0的潜伏期均较健康组明显延长 ,波幅较健康组显著降低 (均为P <0 0 0 1) ;多发腔隙性脑梗死组N2 、P30 0的潜伏期均较单发腔隙性梗死组明显延长 (均为P <0 0 1) ;总智商在 70～ 79分以下的ACI患者 ,其P30 0异常率 (6 5 4 % )较智商在80～ 89以上的ACI患者P30 0异常率 (4 8 1% )显著升高 (P <0 0 0 1)。 结论 ACI患者确有不同程度的智能障碍 ,表现为皮质下痴呆的特征 ;脑梗死灶越多 ,
Objective To explore the characteristics of intellectual impairment and event -related potential(ERP) in the elderly patients with asymptomatic cerebral infarction (ACI). Methods By using WAIS-RC and sensory event-related potential, VIQ, PIQ, FIQ, the latency of all the waves of ERP and the amplitude of P300 were measured in 53 elderly patients with ACI and 50 healthy controls. The 53 ACI patients were divided into a single-infarct cerebral lesion (30 cases) and multi-infarct cerebral lesion (23 cases). Results About 49.1%-58.5% of the patients with ACI showed some degrees of intelligence impairment, all score by WAIS-RC test was significantly lower in patients with ACI than that in healthy controls (P<0.001). Intelligence impairment was more severe in the group with multi-infarct cerebral lesion than that in the group with single-infarct cerebral lesion (P<0.01), and all scores by WAIS-RC test was markedly lower in the multi-infarct cerebral group than that in the single-infarct cerebral group (P<0.001-0.05), manifested as subcortical dementia. The latency of cognitive N 2 and P300 in patients with ACI was significantly prolonged and the amplitude of P300 was markedly lowered as compared with those in the control group (all P<0.001). The latent period of N 2 and P300 in the multi-infarct cerebral group was significantly prolonged than those in the single-infarct cerebral group (all P<0.01). Abnormal rate of P300 was significantly increased in ACI patients (65.4%) with FIQ≤70-79 score than that in patients (48.1%) with FIQ≥80-89 score (P<0.001). Conclusions The patients with ACI manifeste some different degrees of intelligence impairment and shows subcortical dementia. The more cerebral infarct lesion, the more severe intellectual and cognitive impairment.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2004年第3期149-152,共4页
Chinese Journal of Geriatrics
