摘要
近年的研究发现 ,凝血酶是一种多功能丝氨酸蛋白酶 ,除了参与凝血过程外 ,还刺激细胞产生各种炎症反应所必需的炎症介质 ,参与炎症反应过程 ,加重缺血性脑损害的炎症反应 ,进一步产生神经功能损害。文章综述了近年来国内外相关研究的进展和凝血酶对炎症反应的作用机制 ,旨在为临床治疗提供新的线索。
Some recent studies have found that thrombin is a multifunctional serine protease. It not only participates in the processes of coagulation cascade, but also stimulates cells producing inflammatory mediators, which are needed by all inflammatory responses, participating in the processes of inflammatory responses, aggravating the inflammatory response in ischemic cerebral injuries and causing further neurological damage. This article reviews the recent related progresses and the acting mechanism of thrombin in the inflammatory response. The aim is to provide some new clues for clinical treatment.
出处
《国外医学（脑血管疾病分册）》
2004年第5期375-378,共4页
Foreign Medical Sciences Cerebrovascular Diseases
