摘要
目的:研究抑癌基因PTEN在乳腺浸润性导管癌中的表达及其临床意义。方法:采用免疫组化技术(S蛳P)检测50例原发性乳腺浸润性导管癌中PTEN的表达情况。结果:PTEN总的表达缺失率为44 %(22/50)。PTEN表达缺失率随着肿瘤大小、组织学分级和临床分期的增高而升高(P<0.05)。生存时间在10 a以上病例的PTEN表达缺失率显著低于生存时间不足5 a组和5 a～10 a组(P<0.05)。有腋淋巴结转移组和无腋淋巴结转移组的PTEN表达缺失率分别为58.3 %和30.8 %,但统计学分析差异无显著性(P=0.05)。PTEN表达与ER状态关系不大,但两者联合检测可能对临床评估预后更有意义。结论:检测乳腺浸润性导管癌PTEN在蛋白水平的表达缺失状况可能有助于对其预后的判断。
Objective: To study the expression and clinical significance of tumor suppressor gene PTEN in primary breast infiltrative ductal carcinoma. Methods: Immunohistochemical staining(S- P) was used to detect the expression of PTEN in 50 cases of primary breast infiltrative ductal carcinoma samples. Results: Among these 50 samples,the rates of total expressing depletion of PTEN were 44 %(22/50).With the increasing of tumor size,histological grade and clinical stage,the rates of expressing depletion of PTEN raised(P<0.05).When the survival time were ≤60 months,>60 months and <120 months,≥120 months,the rates of expressing depletion of PTEN were 75.0 %,50.0 %and 8.4 ,respectively.There were significant differences among the three groups(P<0.05).The rates of depletion of the PTEN expression of the two groups of tumor with or without axillary lymph nodes metastases were 58.3 % and 30.8 % respectively(P=0.05).But expression of PTEN was not different in ER positive group and ER negative group(P>0.05). Conclusion: The depletion of the expression of PTEN at protein level may contribute to prognostic criterion for breast infiltrative ductal carcinoma.
出处
《肿瘤研究与临床》
CAS
2004年第2期84-87,共4页
Cancer Research and Clinic
关键词
抑癌基因PTEN
免疫组织化学
乳腺癌
Tumor suppressor gene PTEN
Immunohistochemistry
Breast carcinoma
