摘要
综述近年中药实验研究抗非甾体抗炎药胃粘膜损伤主要是通过促进胃粘膜前列腺素合成、抗自由基损伤、增强胃粘液 -碳酸氢盐屏障、改善胃粘膜上皮功能、改善胃粘膜血流和微循环、抗胃酸及胃蛋白酶等途径起作用。研究的中药以益气健脾药最多 ,还有活血化瘀、清热解毒及滋阴生津类中药。认为需进一步研究中药的胃粘膜保护作用是否与调节环氧合酶有关联性。
To summarize the recent experimental studies on the protection of the traditional Chinese for treating the damage of gastric mucosa with Non-steroidal anti-inflammatory drugs:The mechanism includes promoting the prostaglandin synthesis of gastric mucosa,suppressing the damage of free radical,reinforcing the gastric mucus-bicarbonate barrier,ameliorating the gastric mucosal epithelia function,ameliorating gastric mucosal blood flow and microcirculation,inhibiting gastric acid and pepsin.Most of the traditional Chinese materia medica are YI QI JIAN PI,others are HUO XUE HUA YU、QING RE JIE DU and ZI YIN SHENG JIN.More research is needed to clarify the relevance of protection of gastric mucosa and regulation of cyclooxygenase.
出处
《中国实验方剂学杂志》
CAS
2004年第3期62-64,F003,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
胃粘膜损伤
非甾体抗炎药
中药
实验研究
gastric mucosal damage
non-steroidal anti-inflammatory drugs
Chinese materia medica
experimental study
