摘要
目的 研究清热补益中药对急性放射性肠炎的临床治疗效果和大鼠放射诱导肠损伤的组织形态学和一氧化氮水平的影响。方法 临床观察了 2 35例宫颈癌合并放射性肠炎的患者 ,临床治疗中药组 (16 3例 )口服清热补益中药 ,对照组 (72例 )口服诺氟沙星 0 2g ,2次 d +思密达 3g,3次 d。实验大鼠分 4组 ,每组 12只 ,中药组 (清热补益中药 ) ,西药组 (诺氟沙星 ) ,肠炎组 (单纯照射 )和对照组 (正常对照 ) ,观测肠黏膜一氧化氮水平、绒毛数和平均绒毛高度。结果 中药组和对照组的临床显效率分别为 93 87%和 2 0 82 % (P <0 0 1)。动物中药组和西药组肠绒毛数非常显著地多于肠炎组 (P <0 0 0 1) ,平均绒毛高度也非常显著地高于肠炎组 (P <0 0 0 1) ,肠黏膜一氧化氮浓度显著低于肠炎组 (P <0 0 5 ) ,中药组和西药组之间差异无显著性。结论 清热补益中药口服有效 ,疗效显著和起效迅速。清热补益中药对放射性的肠黏膜损伤有保护和促进黏膜再生的作用 ,可抑制一氧化氮的产生 ,减轻放射性肠炎。
Objective To evaluate the therapeutic efficacy of fever-reducing and invigorating Chinese medicine(FRICM) on acute radiation enteritis and effects on nitric oxide level and morphometrics in intestinal mucosa with radiation-induced enteritis in rats. Methods Altogether 235 patients of acute radiation enteritis with carcinoma of uterine cervix were observed.They were divided into two groups:a FRICM group (administered orally with FRICM) and a control group (administered orally with smectite powder 3 g tid and Norfloxacin 0.2 g bid).Forty-eight Wistar rats were divided into four groups:a FRICM group given (FRICM,orally),a western medicine group (Norfloxacin,orally).An enteritis group (irradiation only) and a control group (without irradiation).In these rats intestinal NO concentrations,mean villous height and number of villi/cm were measured. Results The notable effective rates in patients of Chinese herbal and western medicine groups were 93.87% and 20.82% respectively,( P <0.01).In rats,compared with the enteritis group,in both FRICM and western medicine groups there were more intestinal villi ( P <0.001),the villous height was significantly increased( P <0.001) and the intestinal NO concentration was significantly decreased ( P <0.05).There was no significant difference between the FRICM and the Western medicine groups. Conclusion This study demonstrates that the most significant benefit of FRICM in the treament of patients with acute radiation enteritis was orally effective within 24 h.The results of the animal study showed that FRICM could protect intestinal mucosa and accelerate its healing from radiation damages,as well decrease intestinal NO concentration,which might have a beneficial effect in the protection of intestinal mucosa from radiation damage.The mechanism is worthy of further studies. ;
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2004年第1期49-51,共3页
Chinese Journal of Radiological Medicine and Protection
