摘要
目的 探讨妊高征患者血浆及胎盘组织中转化生长因子 β1 (Transforminggrowthfactor-beta 1 ,TGFβ1 )的表达及其临床意义。 方法 用酶联免疫吸附法 (ELISA)检测 6 4例妊高征患者 (妊高征组 )血浆TGFβ1含量 ,同时用免疫组化 (SABC)法测胎盘组织中TGFβ1表达水平 ,与 2 0例正常孕妇 (对照组 )作对比分析。结果 妊高征组血浆TGFβ1水平为 (4 0 6± 0 87)ng/ml,明显高于对照组 (1 82± 0 35 )ng/ml (P <0 0 1 ) ,妊高征组胎盘组织TGFβ1表达较对照组明显增高 (P <0 0 1 ) ,且随病情严重程度的增加而升高。 结论 妊高征患者TGFβ1的表达异常引起滋养细胞浸润不足 ,导致血压升高等变化 ,可能是妊高征的发病因素之一。
Objective To study expression and clinical significance of TGFβ1 in plasma and placenta of pregnancy-induced hypertension(PIH). Methods The level of TGFβ1 in plasma was examined by enzyme linked immunoabsorbent assay(ELISA). The expression of TGFβ1 in placenta from 64 cases of mild, moderate and serve PIH and 20 of normal controls was determined immunohistochemically(SABC methods).Results The TGFβ1 level in PIH group was significantly higher than that in normal group(4 06±0 87)ng/ml vs.(1 82±0 35) ng/ml ( P <0 01). Expression of TGFβ1 in placenta increased significantly elevated in PIH group compared with the normal group( P <0 01), furthermore the elevation is companied with the severty of in PIH group than in the normal group( P <0 01),and further increasing could be found in more severe PIH. Conclusions The elevated expression of TGFβ1 in PIH leads to deficient invasion of the trophoblasts,and results in hypertension.This may be one of the pathogenesis of PIH.
出处
《中国妇产科临床杂志》
2004年第1期40-42,16,共4页
Chinese Journal of Clinical Obstetrics and Gynecology
