摘要
目的:评价系统性红斑狼疮(SLE)患者在使用皮质类固醇治疗中产生的并发损害及与其剂量的相关性。方法:用SLICC/ACRDamageIndex测量SLE活动及其治疗产生的损害,用Cox比例风险模式分析SLE损害同累积剂量、大剂量皮质类固醇和冲击治疗的相对危险度。结果:骨质疏松性骨折、冠状动脉疾病和白内障与泼尼松累积量相关,无菌性骨坏死和脑血管意外与使用大剂量皮质类固醇相关,慢性认知障碍与冲击治疗相关。结论:累积和大剂量泼尼松与SLE患者持久的器官损害呈显著性相关。
Objective: To evaluate the correlation between corticosteroid dosage and organ damages from steroid side-effects in patients with SLE. Methods: The occurrence and data of organ damage, as by SLICC/ACR Damage Index, were determined for 539 patients. The damage risk associated with cumulative prednisone dose, high-dose prednisone, and pulse methylprednisone was estimated by using regression analyses of Cox proportional hazards. Results: The cumulative prednisone dose was significantly associated with the development of osteoporotic fractures (RR 2.5), symptomatic coronary artery disease (RR 1.7), and cataracts (RR 1.9). Each 2-month exposure to high-dose prednisone was associated with a 1.2-fold increase in the risk of both vascular necrosis and stroke. Conclusions: SLE patients receiving long-term prednisone therapy were at high risk of morbidity due to permanent organ damages.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2003年第7期388-390,共3页
Journal of Clinical Dermatology
关键词
红斑狼疮
系统性
皮质类固醇
不良反应
器官损害
lupus erythematosus, systemic
corticosteroids
side effects
organ damage
