摘要
目的:探讨甘露醇(MT)致急性肾衰(ARF)的规律.方法:对1980～1996年国内发表的MT致ARF文献进行荟萃分析.结果:MT致ARF的病死率(CFR)为40.4%,透析与非透析组CFR分别为23.7%和44.2%(P<O.025).MT累积量和日平均量分别为1140.4g和233.3g,但存活组与死亡组均无统计学差异(P>0.05).ARF患者BUN和Cr的平均值较正常值分别升高3.7和2.7倍.结论:MT致ARF的CFR是很高的.透析是治疗ARF最有效的方法.为防止ARF发生,MT剂量宜控制在200g/d以下.BUN和Cr的升高对ARF有诊断意义但无预后判断价值.
To understand the mechanism of mannitol-induced acute renal failure (MIARF), 228 cases of MIARF reported in domestic literature during 1980-1996 in China were reviewed. Results showed that the cases fatality rate (CFR) of the MIARF was 40.4% (82/203). The CFRs of the non-dialysis and dialysis group were 44.2% (73/165) and 23.7% (9/38) respectively (P<0.025). The mean daily mannitol dose and accumulative amount were 233.3±164.8g and 1140.4±696.7g respectively. The serum urea nitrogen and creatinine of MIARF were increased 3.7 and 2.7 times respectively, as compared with normal value respectively. It is concluded that the CFR of MIARF was very high. The dialysis is the most efficient way of treating patients with MIARF. The Mannitol dose should be controlled under 200g/d to prevent ARF. Increased BUN and Cr have diagnostic but no prognostic implications.
出处
《药物流行病学杂志》
CAS
1998年第1期23-26,共4页
Chinese Journal of Pharmacoepidemiology
