摘要
目前普遍认为ACE(血管紧张素转换酶)的水平和心血管的形态、功能密切相关。ACE基因的多态性是人耐力素质优劣的决定性因素之一。为了解运动员血管紧张素转换酶(ACE)基因插入或缺失(I/D)多态性情况,探讨ACE基因多态性与有氧耐力可能的关系,用聚合酶链反应(PCR)技术检测20例运动员和20例健康对照者的ACE基因多态性。结果位于ACE基因16内含子的I/D多态性经PCR扩增后呈三种基因型:纯合子插入型(II)、纯合子缺失型(DD)和杂合子插入或缺失型(ID)。耐力运动员组II基因型和I等位基因频率显著高于健康对照组。结果表明ACE基因可能在运动员的有氧耐力中起重要作用。
Angiotensin-converting enzyme in human skeletal muscle can be encoded by either of two variants of the ACE gene, one of which carries an insertion of 287 base pairs. This longer allele gives rise to lower enzyme activity, and is associated with enhanced endurance performance and an anabolic response to intense exercise training. The PCR was used to determine the genotypes of an I/D polymorphism in intron 16 of the ACE gene in 40 athletes and 20 healthy subjects as controls. The results show the genotype II and I allele frequency were significantly higher in endurance athlete (35%,0.650) than in healthy group(15%,0.525). Further work will be needed to explore the mechanisms underlying these observations.
出处
《乐山师范学院学报》
2004年第5期116-118,共3页
Journal of Leshan Normal University
