摘要
目的 :评价左氧氟沙星片和头孢噻肟钠粉针剂治疗细菌性感染的有效性和安全性。方法 :74例确认为细菌性感染的患者随机分为 2组 ,试验组 37例 ,口服左氧氟沙星片 2 0 0mg,bid ,对照组 37例 ,头孢噻肟粉针剂 3g ,静脉滴注 ,bid。 2组疗程均为 5d～1 4d。对所有患者在治疗前及治疗结束后进行评估。结果 :治疗组与对照组痊愈率分别为 81 3%与 78 3%。有效率为 89 2 %与83 8% ,细菌消除率为 93 9%与 90 3% :不良反应发生率为 8 1 %和 1 0 8% ,2组各项指标比较无显著统计学差异 (P >0 0 5 )。结论 :对细菌性感染患者 ,左氧氟沙星片与头孢噻肟粉针剂疗效相当。
OBJECTIVE:To observe the effect and safety of levofloxacin and cefotaxime in the treatment of bacterial infections.METHODS:74 patients were randomly divided into trail group and control group.37 patients in the trail group were treated with levofloxacin 200mg,po,bid,for 5d～14d and control group treated with cefotaxime 3g,iv,bid,for 5d～14d too. RESULTS: The clinical cure rates in trail group and control group were 81 3% versus 78 3%; effective rates were 89 2% versus 83 8%; bacterial eradication rates were 93 9% versus 90 3%;the incidence of adverse reactions in the 2 groups were 8 1% versus 10 8%.There was no significant statistical difference between the 2 groups( P >0 05).CONCLUSION: Levofloxacin and cefotaxime are effective antibiotic agents in the treatment of bacterial infections,levofloxacin for oral use is more convenient for patients.
出处
《中国医院用药评价与分析》
2004年第2期84-86,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
左氧氟沙星片
细菌性感染
喹诺酮类
抗菌剂
levofloxacin
cefotaxime
bacterial infection
clinical efficacy
safety
