摘要
目的 :分析多种因素对非霍奇金淋巴瘤 (NHL)预后的影响。方法 :通过SABC法进行免疫分型 ,采用Kaplan Meier法分析患者治疗后的生存期 ,采用Cox比例风险模型分析影响预后的因素。 结果 :B细胞来源 NHL(B NHL)发病率为 6 3.3% ,T细胞来源 NHL(T NHL)为 36 .7% ;低度恶性占 17.6 % ,中、高度恶性占 74 .1%。1、2、3、5年生存率 :低度恶性患者为 92 .1%、84 .5 %、6 5 .1%、4 5 .1% ;中、高度恶性患者为 84 .9%、6 7.5 %、4 7.6 %、2 8.4 %。Ⅰ、Ⅱ期患者为 98.8%、91.5 %、87.5 %、70 .3% ;Ⅲ期、Ⅳ期患者为 6 2 .1%、5 5 .5 %、4 0 .1%、2 3.8%。T NHL为 70 .8%、5 3.5 %、4 7.7%、30 .2 % ;B NHL为 82 .1%、70 .5 %、6 1.1%、5 0 .1%。结论 :年龄、乳酸脱氢酶水平、恶性程度、临床分期、免疫分型、身体状况评分 (PS)是影响NHL预后的重要因素。
Objective:To analyse the influence of factors on the prognosis of non-Hodgkin's Lymphoma.Method:Immunological phenotyping was carried out by SABC, Kaplan-Meier was used for survival rate and Cox regression model for prognostic factors. Result:The incidence of B cell NHL was 63.3%, T cell was 36.7%, low grade was 17.6% , middle and high grade were 74.1% . 1、2、3 and 5 years survival rate: low grade were 92.1%、 84.5%、 65.1% and 45.1%, middle and high grade were 84.9%、 67.5%、 47.6% and 28.4%, stageⅠ、Ⅱ were 98.8%、 91.5%、 87.5% and 70.3%, stage Ⅲ、Ⅳ were 62.1%、 55.5%、 40.1% and 23.8%, B-NHL were 82.1%、 70.5%、 61.1% and 50.1%, T-NHL were 70.8%、 53.5%、 47.7% and 30.2%. Conclusion:Age, T ov B classi fication, grade, staging, LDH level and PS are the important factors which affect on NHL prognoses.
出处
《临床血液学杂志》
CAS
2004年第3期146-148,共3页
Journal of Clinical Hematology
关键词
非霍奇金淋巴瘤
生存期
预后
non-Hodgkin's Lymphoma
Survival time
Prognostic factors
