摘要
目的探讨影响儿童非霍奇金淋巴瘤（NHL）预后的因素。方法对儿童医学中心1996年1月-2000年12月经病理确诊为NHL患儿30例,根据可能影响预后的因素,包括年龄、性别、免疫分型、全身症状、肿块大小、骨髓浸润、纵隔浸润、肝大或浸润、脾大或浸润及化疗早期反应将患者分组,比较组间生存率的差异。生存统计采用Kaplan-Meier法,组间比较采用Logrank检验。结果巨大肿块组3年生存率明显好于无巨大肿块组（P〈0.01）;骨髓无浸润组的3年生存率明显好于有浸润组（P〈0.01）;无脾大或浸润组3年无病生存率（DFS）好于有脾大或浸润组（P=0.0255）,而3年总生存率二组间比较无显著差异（P=0.0843）。而以其他临床特征分组,组间无显著差异（P〉0.05）。结论有否骨髓浸润和肿块大小对NHL患儿预后有非常显著的影响,而是否有脾大或浸润对NHL患儿DFS有一定影响。
Objective To analyze the factors affecting prognosis of children with non-Hodgkin′s lymphomas（NHL）.Methods Thirty patients of childhood NHL histologically proven in Shanghai children′s medical center from Jan.1996 to Dec.2000 were analyzed.The patients were divided into groups according to some clinical factors that may have predictive significance including age,gender,immunologic phenotype,general system symptom,the size of tumor bulk,bone marrow involvement,mediastinal involvement,hepatomegaly or liver involvement,splenomegaly or spleen involvement and early response to chemotherapy,then the difference of survival rate were compared between groups.Survival analysis was performed by the Kaplan-Meier method,and difference between groups were campared using the Log-rank test.Results The 3-year survival rate was better in patients without giant tumor bulk than that with giant tumor bulk（P〈0.01）.The 3-year survival rate was also better in the patients without bone marrow involvement than that with bone marrow involvement（P〈0.01）.The 3-year disease-free survival rate as better in the patients without splenomegaly or spleen involvement than that with splenomegaly or spleen involvement（P=0.025 5）.While there were no significant differences of 3-year overall survival（P=0.084 3）.There were no significant differences of the other clinical characteristics （P〉0.05）.Conclusions Bone marrow involvement and the size of tumor bulk have very significant influence on prognosis of childhood NHL,and splenomegaly or spleen involvement have significant influence on disease-free survival.It can′t be proven in childhood NHL in this study.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第3期200-201,共2页
Journal of Applied Clinical Pediatrics
关键词
非霍奇金淋巴瘤
儿童
预后
non-Hodgkin′s lymphoma,child,prognosis
