摘要
目的 :比较 1,6 二磷酸果糖锌 (Zn FDP)和葡萄糖酸锌 (Zn G)的药动学参数 ,以探讨Zn FDP药动学特征 ,为该药临床应用提供基础资料。方法 :采用电感耦合等离子体发射光谱法对小鼠口服Zn FDP和Zn G后的血锌含量分别进行药动学测定。结果 :Zn FDP和Zn G的Ke 分别为 0 .2 7± 0 .12和 0 .4 1±0 .0 3h ,tmax分别为 1.6 5± 0 .0 4和 1.4 3± 0 .0 5h ,Cmax分别为 9.2 7± 0 .2 5和 13.4 6± 0 .16mg·L-1,AUC分别为 4 7.4 5± 2 .11和 5 7.6 7± 5 .80mg·h-1·L-1。结论 :Zn FDP给药后血锌低于Zn G给药后血锌含量 ,但心、肝、脑、肾 4个脏器锌含量却无显著差异 ,表明Zn FDP吸收不及Zn G ,但由血液转运进入组织却优于Zn G。
AIM : To compare pharmacokinetic character between zinc gluconate (Zn-G) and zinc fructose-1,6- diphosphate(Zn-FDP)in mice. METHODS : Inductively coupled plasma (ICP) was used to measure the zinc serum concentration at regular time-points in mice, and the pharmacokinetic parameters of both drugs were calculated. RESULTS : The values of K e (h -1) of Zn-FDP and Zn-G were 0.27± 0.12 and 0.41± 0.03, respectively; the t max (h), 1.65± 0.04 and 1.43± 0.05; the C max (mg·L -1), 9.27± 0.25 and 13.46± 0.16; and AUC (mg·h -1·L -1), 47.45± 2.11 and 57.67± 5.80. CONCLUSION : The blood zinc content after Zn-FDP orally administered is lower than that one after Zn-G, but there is no significance in the zinc content differences among heart, liver, brain and kidney, suggesting that Zn-FDP is not as good as Zn-G in absorption.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2004年第4期417-419,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
