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NKG2D及其配体研究进展 被引量：6

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摘要 NKG2D是较为独特的NK细胞活化性受体 ,其配体具有多样性 ,因而其识别机制较独特 ;其表达范围不仅局限于NK细胞 ,还在T细胞、巨噬细胞、树突状细胞中有表达 ,功能上 ,不仅有直接刺激作用 ,还能作为协同刺激分子传递第二信号。NKG2D及其配体的研究对抗肿瘤免疫、抗感染免疫、自身免疫病的认识具有重要意义。本文对NKG2D及其配体的研究进展作一综述。
作者 宫伟雁 冯永堂
机构地区 潍坊医学院免疫学教研室（硕士） 潍坊医学院免疫学教研室
出处 《国外医学（免疫学分册）》 2004年第3期160-164,共5页 Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
关键词 NKG2D NKG2D配体
分类号 R392.11 [医药卫生—免疫学]
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参考文献19

  • 1Ryan JC,Naper C,Hayashi S,et al.Physiologic functions of activating natural killer (NK) complex-encoded receptors on NK cells.[J].Immunol Rev ,2001,181:126-137.
  • 2Ahmad T,Marshell SE,Mulcahy-Hawes K,et al.High resolution MIC genotyping:design and application to the investigation of inflammatory bowel disease susceptibility.[J].Tissue Antigens,2002,60(2):164-179.
  • 3Radaev S,Kattah M,Zou ZC,et al.Making sense of the diverse ligand recognition by NKG2D.[J].J Immunol,2002,169:6279-6285.
  • 4Ho EL,Carayannopoulos LN,Poursine-Laurent J,et al.Costimulation of multiple NK cell activation receptors by NKG2D.[J].J Immunol,2002,169:3667-3675.
  • 5Roberts AI,Lee L,Schwarz E,et al.NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment.[J].J Immunol,2001,167:5527-5530.
  • 6Gilfillan S,Ho EL,Cella M,et al.NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.[J].Nat Immunol,2002,3(12):1150-1155.
  • 7Zompi S,Hamerman JA,Ogasawara K,et al.NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.[J].Nat Immunol,2003,4(6):565-572.
  • 8Trinchieri G.The choices of a natural killer.[J].Nat Immunol,2003,4(6):509-510.
  • 9Diefenbach A,Jensen ER,Jamleson AM,et al.Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity.[J].Nature,2001,413:165-171.
  • 10Groh V,Wu J,Yee C,et al.Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.[J].Nature,2002,419:734-738.

同被引文献92

  • 1Yongyan Chen,Min Cheng,Zhigang Tian.Hepatitis B Virus Down-Regulates Expressions of MHC Class I Molecules on Hepatoplastoma Cell Line[J].Cellular & Molecular Immunology,2006,3(5):373-378. 被引量：14
  • 2Wehe SA, Sinsger C, Lutz SZ, et al. Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycopretein. Eur J Immunol,2003, 33 ( 1 ) : 194-203.
  • 3Wu J, Chalupny NJ, MaMey TJ, et al. IntraceUular retention of the MHC class I-related chain B ligand of NKG2D by the human CMV UL16 glycoprotein. J Irmnuno1,2003,170 ( 8 ) :4196-4200.
  • 4Ogasawara K, Hamerman JA, Ehrlich Lr, et al. NKG2D blockade prevents autoinunune diabetes in NOD mice. Immunity, 2004, 20 (6) :757-767.
  • 5Poirot L, Benoist C, Mathis D. Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity. Proc Natl Acad Sci USA ,2004,101 (21) :8102-8107.
  • 6Hue S, Mention JJ, Monteiro RC, et al. A direct role for NKG2D/ MICA interaction in villous atrophy during celiac disease. Immunity,2004, 21 (3) :367-377.
  • 7Meresse B, Chen Z, Ciszewski C, et al. Coordinated induction by ILl5 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity, 2004, 21 (3) :357-366.
  • 8Greh V, Bruhl A, E1-Gabalawy H, et al. Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc Nail Acad Sci USA,2003,100 ( 16 ) :9452 - 9457.
  • 9Horng T, Bezbradica JS, Medzhitov R. NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol. 2007, 8(12) : 1345-1352.
  • 10Groh V, Rhinehart R, Randolph-Habecker J, Co-stimulation of CD8 + αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nature Immunol,2001,2(3) :255 - 260.

引证文献6

二级引证文献10

国外医学（免疫学分册）
2004年 第3期

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