摘要
目的:探讨妊娠高血压综合征(妊高征)患者血尿酸浓度检测的临床价值。方法:通过对住院的156例妊高征及156例正常孕妇采用尿酸酶法检测血尿酸(UA)浓度,同时观测血尿素氮(BUN)、肌酐(Cr)、血球压积(Hct)及血小板计数(Pt)。结果:妊高征组血UA浓度显著高于正常孕妇[(347.2±107.6)μmol/L vs(235.5±43.2)μmol/L,P<0.01],血UA浓度与妊高征病情严重程度呈正相关[(r(1)=0.39,r(2)=0.48,r(3)=0.59,P<0.015]。妊高征患者血UA升高时BUN、Cr、Hct趋于增高,Pt趋于降低,血UA>350μmol/L]时围产儿死亡率显著增高(P<0.01)。结论:血UA水平反应了妊高征疾病严重程度,可作为判断胎儿预后的生化指标。
Objective: To investigate the clinical significance of plasma uric acid measurement in pregnancy induced hypertension (PIH) patients. Methods: A total of 156 PIH patients and 156 normal pregnant women who were hospitalized entered this study. The plasma uric acid was tested with uricase assay. The blood urea nitrogen (BUN), creatinine (Cr), hematocrit (Hct) and platelet (Pt) count were measured at the same time. Results: The plasma uric acid concentrations were significantly higher in PIH group than those in normal pregnant group [(347.2±107. 6)μmol/L vs (235. 5±43. 2)μmol/L, P <0. 01]; It has shown that there was a positive correlation between uric acid concentration and the disease severity[r(1)=0.39, r(2)=0.48, r(3)=0.59, P< 0.05]; There was a trend that the increased UA was associated with an increase of BUN, Cr, Hct and a decrease of platelet count; There was significantly higher perinatal mortality in PIH group than that in normal pregnant women when plasma uric acid was above 350 μmol/L( P<0.01). Conclusion:The plasma uric acid levels are believed to be the reflection of patients in progression of PIH and can be used as a biochemical marker for judging the fetal outcome.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2004年第3期265-266,279,共3页
Journal of Nanjing Medical University(Natural Sciences)
关键词
妊娠并发症
心血管
高血压
尿酸
pregnancy complication
cardiovascular
hypertension
uric acid
