摘要
目的 探讨应用房间隔穿刺和球囊扩张建立可控大小房间隔缺损 (ASD)动物模型的新方法。方法 选用健康杂种犬 14只 ,在X线引导下 ,应用房间隔穿刺、扩张管和球囊扩张 ,建立可控大小的ASD动物模型。结果 除早期 2只死亡外 ,无其他并发症 ,12只犬均成功建立ASD模型。结论 该方法具有创伤小、操作简便、可重复性好、大小可控、X线投照时间短等优点。
Objective To explore the novel method to establish animal model of controllable sized atrial septal defect. Methods Fourteen dogs of both sexes were selected,with weight ranging from 15 to 20kg. Under guidance of fluoroscopy,ASD was established by using Brokenbrough needle and balloon dilatation. Results Tow dogs died of cardiac tamponade.Other twelve dogs had ASD created successfully without complication. Conclusion The method has the advantages of easy manipulation , size controllable and small amount of fluoroscopy exposure.
出处
《介入放射学杂志》
CSCD
2004年第2期159-160,共2页
Journal of Interventional Radiology
