摘要
目的 研究血清高敏C反应蛋白 (hs CRP)水平与冠心病斑块稳定程度的相关性。方法 用酶联免疫吸附法 (ELISA)检测了 138例冠心病患者 (2 8例急性心肌梗死 ,6 6例不稳定型心绞痛 ,4 4例稳定型心绞痛 )及 2 8例非冠心病对照组的hs CRP的水平 ,并对冠心病患者进行冠状动脉造影病变形态学分析 ,比较不同类型的冠心病及不同形态斑块的hs CRP水平。结果 血清hs CRP在急性心肌梗死组 (16 .2 5± 1.2 7)mg/L和不稳定型心绞痛组 (11.4 1±4 .89)mg/L明显高于稳定型心绞痛组 (4 .82± 3.94 )mg/L和非冠心病组 (2 .70± 1.95 )mg/L(P均 <0 .0 5 )。血清hs CRP在Ⅱ型斑块组中的水平 (14 .5 0± 4 .6 6 )mg/L明显高于其他型斑块组 (6 .82± 5 .6 3)mg/L及非冠心病组 (2 .70± 1.95 )mg/L(P <0 .0 1)。结论 血清hs CRP水平与冠心病斑块稳定性有关。冠状动脉造影斑块分型结合hs CRP水平 。
Objective To study the relationship between serum high sensitive C-reactive protein and plaque stability of coronary lesion.Methods Levels of serum high sensitive C-reactive protein (hs-CRP) were measured among 138 patients with coronary heart disease (CHD) including 28 cases of acute myocardial infraction(AMI),66 cases of unstable angina pectoris(UAP),44 cases of stable angina pectoris(SAP) and 28 cases of without CHD as control by enzyme-linked immunoassay.Anginographic morphology of the coronary lesion was assessed in patients with CHD.Then,the serum hs-CRP levels were compared among different types of CHD and plaque.Results Serum hs-CRP levels were significantly higher in the AMI group ( 16.25± 1.27) mg/L and UAP group ( 11.41± 4.89) mg/L than in the SAP group ( 4.82± 3.94) mg/L and without CHD group( 2.70± 1.95) mg/L(P< 0.05).Serum hs-CRP levels were significantly higher in the typeⅡlesions( 14.50± 4.66) mg/L than in the other type lesions group ( 6.82± 5.63) mg/L and in the control group ( 2.70± 1.95) mg/L (P< 0.01).Conclusion Serum hs-CRP level was closely associated with plaque stability of coronary lesion.The plaque stability of coronary lesion can be preferably estimated by linking up anginographic morphology of the coronary lesion and serum hs-CRP levels.
出处
《临床荟萃》
CAS
北大核心
2004年第9期488-490,共3页
Clinical Focus
