摘要
目的 观察18F 脱氧葡萄糖 (FDG)PET脑显像鉴别诊断阿尔茨海默病 (AD)与血管性痴呆 (VD)的价值。方法 分别对 10例AD、11例VD及 12例对照者进行18F FDGPET脑显像 ,采用统计参数图 (SPM)方法及感兴趣区 (ROI)方法进行分析 ,比较AD及VD的显像特点。结果 SPM图像显示 ,AD组患者两侧大脑皮层顶叶、颞叶、额叶及后扣带回等部位葡萄糖代谢明显降低 ,左、右不对称 ;而两侧皮层下基底节区等结构代谢不受影响。VD组患者代谢弥漫性降低 ,遍及大脑皮层及皮层下结构。ROI分析表明 ,AD组患者大脑皮层顶叶、颞叶、额叶放射性降低 ,差异有显著性 (P <0 0 5 ) ,皮层下神经核团等无明显变化。而VD组患者仅左侧额叶及右侧壳核放射性降低 ,差异有显著性 (P <0 0 5 )。结论 PET脑显像可有效诊断AD并鉴别诊断AD与VD。
Objective To map the specific foci of Alzheimer's disease (AD) and vascular dementia (VD) with PET brain imaging,as well as to differentiate AD and VD. Methods There were 10 AD patients,11 VD patients and 12 control subjects who were studied with PET using 18 F-fluorodeoxyglucose (FDG) as radiotracer. Statistical parameter mapping (SPM) method and region of interest (ROI) method were used to analyze the PET data and to compare AD/VD imaging results. Results SPM results showed that cerebral metabolic rates of glucose decreased in bilateral parietal lobe,temporal lobe,frontal lobe and post cingule in AD patients compared with control subjects were obviously decreased,and showed right/left hemispheric asymmetry. The hypometabolism spared basal ganglia and other regions. In VD patients,the metabolic deficits were variable and asymmetric and could be found in both cortical and subcortical areas. ROI statistical results showed that the radiocounts in the parietal lobe,temporal lobe and frontal lobe were significantly lower in the AD patients than in the control subjects( P <0.05). Subcortical areas were not significantly changed. In VD patients,only left frontal lobe and right putamen showed lower radiocounts( P <0.05). Conclusion PET can show a distinct typical pattern of hypometabolism in the AD patients,while no specific pattern is showed in the VD patients and it can provide an effective imaging tool for the clinician to diagnose AD,and to differentiate AD from VD.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2004年第1期30-32,i002,共4页
Chinese Journal of Nuclear Medicine
