摘要
目的:探讨新生儿HBeAg在HBV宫内感染中的作用.方法:收集HBsAg阳性住院待产孕妇,采ELISA方法和abbott试剂对产妇和新生儿HBeAg、HBsAg进行检测结果:57例孕妇血清经实验室复查,HBsAg均阳性,其中HBeAg阳性孕妇15例.15例HBeAg阳性孕妇所产的16例新生儿有11例HBeAg阳性(68.75%).新生儿HBsAg阳性3例,全部产自于HBeAg阳性母亲,且其外周血HBeAg均阳性.统计分析显示新生儿HBeAg是HBV宫内感染的危险因素(P<0.05).结论:新生儿HBeAg在HBV官内感染过程中起重要作用.
AIM: To investigate the effect of HBeAg on the hepatitis B virus vertical transmission in neonates. METHODS: HBsAg positive pregnant women were enrolled, and ELISA or Abbott was employed to detect the HBeAg and HBsAg in the peripheral blood of neonates and their mothers. RESULTS: Fifty-seven HBsAg positive pregnant women were reconfirmed as HBsAg positive. Fifteen of them were detected as HBeAg positive. Eleven of 16 neonates born to 15 HBeAg positive mother were detected as HBe Ag positive. Three neonates diagnosed as HBsAg positive by ELISA or Abbott reagents were detected as HBeAg positive. Statistic analysis indicated that HBeAg in newborns was an important risk factor. CONCLUSION: HBeAg in neonates played an important role during HBV vertical transmission.
出处
《世界华人消化杂志》
CAS
2004年第2期298-301,共4页
World Chinese Journal of Digestology
基金
国家自然科学基金课题
No.3203023~~
