摘要
目的探讨不同免疫方法对乙型肝炎(乙肝)病毒(HBV)母婴传播的阻断作用。方法以HBsAg阳性孕妇及其婴儿为研究对象,按不同阻断方式分组,孕晚期孕妇及其新生儿注射乙肝免疫球蛋白(HBIG),同时对新生儿联合采用乙肝疫苗(HBVV)注射(A组,126例);仅新生儿联合使用HBIG及HBVV(B组,102例);仅新生儿进行HBVV接种(C组,215例)。检测A组孕妇血液HBV DNA含量变化,比较各组新生儿宫内感染率及1岁后感染率。结果 A组孕妇使用HBIG前后血液HBVDNA含量差异无统计学意义;A、B、C组新生儿宫内感染率分别为4.76%、4.92%和4.65%,差异无统计学意义,新生儿1年后感染率分别为5.92%、4.93%、8.3%,C组感染率与A、B组比较差异有统计学意义(P<0.05)。结论孕期使用HBIG不能降低孕妇病毒载量,对HBV宫内传播无保护作用;对新生儿联合使用HBIG及HBVV能减低HBV感染率。
Objective To investigate the effect of different immunization methods on interrupting maternal infant vertical trans- mission of hepatitis B virus. Methods HBsAg positive pregnant women and infants were divided into three groups. In group A（126 cases） ,pregnant women and the infants were injected with hepatitis B immunoglobulin（HBIG）during pregnancy since the 28th week of gestation and HBVae was injected to their infants;while in group B（102 cases）pregnant ,women were not injected with HBIG;in control group C（215 cases）,the infant were injected with HBVac only. HBV DNA in maternal sera of group A were de- tected and compare the copies before injection with after injection. Incidence of HBV intrauterine transmission was compared and in- cidence of HBV infection in 1 year infant in 3 groups. Results The difference was not significant between before injection and after iniection in group A pregnant women. Incidence of HBV intrauterine transmission was 4.76 %（6/126） in A,.4.92% （5/102） in B,4. 65 % （10/215） in C and the difference was not significant. Incidence of HBV infection in the A and B was significantly lower than that of C in one year infants（5.92% in A,4.93% in B vs 8.3% in C,P〈0.05）. Conclusion HBIG administration during pregnancy didn＇t decrease copies of HBV DNA, and the protective effect on HBV intrauterine infection was not found combining HBIG with HBVac can decrease incidence of HBV infection in infants.
出处
《国际检验医学杂志》
CAS
2011年第2期196-197,共2页
International Journal of Laboratory Medicine
关键词
免疫球蛋白类
疾病传播
肝炎
乙型
immunoglobulins
disease transmission
hepatitis B
