摘要
目的:初步探讨基质金属蛋白酶与恶性腹水的关系.方法:收集腹水患者67例,男38例,女29例.肝硬化腹水36例,结核性腹水8例,恶性腹水23例.用明胶酶谱法测定基质金属蛋白酶活性.结果:肝硬化腹水、结核性腹水不能检出基质金属蛋白酶-2.-9(MMP-2,-9)活性,而恶性腹水MMP-2检出率为87.0%,MMP-9检出率为78.3%,且MMP-2活性高于MMP-9活性(0.01<P=0.022<0.05).结论:基质金属蛋白酶活性检测对于良、恶性腹水的鉴别诊断有重要价值,他可能与恶性腹水形成有关.
AIM: To explore the relationship between matrix metallopro-teinase and malignant ascites. METHODS: A total of 67 patients, 38 male and 29 female, including cirrhotic ascites (36 cases), tuberculous ascites (8 cases) and malignant ascites (23 cases) were collected and studied in the following experiment. The matrix metallopro-teinase activity was detected by gelatin zymography. RESULTS: The activity of matrix metalloproteinase-2 and matrix metalloproteinase -9 could not be detected in ascites of hepatic cirrhosis and tuberculous peritonitis but could be detected in 87.0% and 78.3% of malignant ascites (n =23) respectively. Furthermore, the activity of MMP-2 was higher than that of MMP-9 (0.01<P=0.022<0.05). CONCLUSION: The detection of matrix metalloproteinase activity is useful in differential diagnosis between benign and malignant ascites. Matrix metalloproteinase may be related to the formation of malignant ascites.
出处
《世界华人消化杂志》
CAS
2004年第2期376-378,共3页
World Chinese Journal of Digestology
基金
湖北省自然科学基金资助项目
No.99J163~~
