摘要
目的 研究低体重早产儿维生素K缺乏状况及其与脑室出血的相关性。方法 采用酶联免疫吸附法 (ELISA)检测 5 4例孕周 <34周、体质量 90 4～ 2 15 7g早产儿静脉血凝血酶原前体蛋白 (PIVKA Ⅱ ) ,并于生后3～ 5d行头颅B超检查 ,诊断有无脑室出血。结果 PIVKA Ⅱ阳性 17例 ,低体重早产儿维生素K缺乏发生率为 31.5 % (17/ 5 4 ) ,低体重早产儿脑室出血发生率为 4 8.7% (19/ 39) ,维生素K缺乏并脑室出血 4例 ,其中重度脑室出血 3例。窒息、低出生体重是主要致病因素。结论 低体重早产儿存在维生素K缺乏 ,相当一部分早产儿存在脑室出血 ,维生素K缺乏虽不是脑室出血的主要致病因素 ,但其他致病因素也可能加重脑室出血的严重程度 。
Objective To study the incidence of vitamin K deficiency in low-birth weight premature infants and its relationship with intraventricular hemorrhage.Methods We use emzymoimmunoelectrophoresis to detect prophrombin protein precursors(PIVKA-Ⅱ) in vein blood in premature infants <34 weeks′ gestation.Intraventricular hemorrhage was diagnosed by examinations of cranial ultrasound done on day 3 to 5.Results The incidence of vitamin K deficiency was 31.5 %(17/54) and the incidence of intraventricular hemorrhage was 48.7%(19/39).Asphyxia and low birth weight were mainly sick factors. Intraventricular hemorrhage occured in 4 cases of vitamin K deficiency,of which 3 cases were severe intraventricular hemorrhage.Conclusions Low-birth weight premature infants often have vitamin K deficient and some occur intraventricular hemorrhage.Although the deficiency of vitamin K is not the mainly sick factor, it maybe increases the danger of severity of intraventricular hemorrhage.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2004年第4期269-270,共2页
Journal of Applied Clinical Pediatrics
关键词
婴儿
早产
低体重
维生素K缺乏
脑室出血
low-birth weight premature infant
vitamin K deficiency
intraventricular hemorrhage
