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1,4-双(9-O-奎宁)-2,3-二氮杂萘-OsO_4催化烯烃的不对称氨羟化反应 被引量：8

Asymmetric Aminohydroxylation of Olefins Catalyzed by 1,4-Bis(9-O-quininyl)phthalazine-OsO_4 Complex
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摘要 在氧化 -供氮试剂 N -氯代氨基甲酸苄酯存在下 ,1 ,4-双 ( 9-O-奎宁 ) -2 ,3 -二氮杂萘 -Os O4催化剂在 5种烯烃的不对称氨羟化反应中表现出极高的对映选择性 ( 85 %～ 99% e.e.)和区域选择性 ,产率 48%～ 68% . Five olefins were aminohydroxylated enantiomerically catalyzed by 1,4-bis(9-O-quininyl)phthalazine-OsO 4 complex in the presence of benzyl N-chlorocarbamate(oxidant and nitrogen source). Excellent enantioselectivity(85%—99% e.e.) as well as specific regio and chemoselectivity were observed and isolated yield of the products 48%—68% was achieved. The results are comparable to those of the best catalyst reported for AA reaction.
作者 程司堃 匡永清 路丽华 李晓晔 张生勇
机构地区 第四军医大学化学教研室
出处 《高等学校化学学报》 SCIE EI CAS CSCD 北大核心 2004年第4期651-653,共3页 Chemical Journal of Chinese Universities
基金 国家自然科学基金 (批准号 :2 9972 0 5 5 2 0 0 0 2 0 0 8)资助
关键词 1 4-双(9-O-奎宁)-2 3-二氮杂萘-OsO4 烯烃 不对称氨羟化反应 催化剂 手性Β-氨基醇 Bis(9-O-quininyl)phthalazine Asymmetric aminohydroxylation Chiral β-amino alcohol
分类号 O623.12 [理学—有机化学] O643.36 [理学—物理化学]
  • 相关文献

参考文献10

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二级参考文献9

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共引文献9

同被引文献47

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引证文献8

二级引证文献5

高等学校化学学报
2004年 第4期

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