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不对称二羟化反应制备(2R,3S)-2,3-二羟基-3-苯丙酸乙酯 被引量：1

Preparation of Ethyl (2R,3S)-2,3-Dihydroxy-3-phenylpropionate by Asymmetric Dihydroxylation
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摘要 合成了两种可回收利用的小分子配体,并在两种不同体系的Sharpless不对称二羟化反应中用于催化肉桂酸乙酯,以合成紫杉醇的重要中间体(2R,3S)-2,3-二羟基-3-苯丙酸乙酯。结果表明,两种配体在叔丁醇-水(1∶1)和丙酮-水(10∶1)体系中的催化性能均良好,收率85%～95%,ee可达95%以上,且重复使用3次后收率和ee基本不变。 Two recyclable ligands were prepared and applied to Sharpless asymmetric dihydroxylation reaction in two solvent systems for preparation of ethyl （2R,3S） -2,3-dihydroxy-3-phenylpropionate, the C13 side chain of paclitaxel, from ethyl cinnamate. A product of ee over 95% and 85% - 95% yield was obtained even after the ligands were reused for three times.
作者 陈惠 罗晶 赵安东 孙晓莉
机构地区 第四军医大学化学教研室 陕西省药品检验所
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2005年第9期526-528,共3页 Chinese Journal of Pharmaceuticals
关键词 (2R 3S)-2 3-二羟基-3-苯丙酸乙酯 Sharpless不对称二羟化反应 手性配体 不对称催化 紫杉醇 中间体 合成 （2R,3S）-2,3-dihydroxy-3-phenylpropionate Sharpless asymmetric dihydroxylation reaction chiral ligand asymmetric catalysis paclitaxel intermediate synthesis
分类号 O625.523 [理学—有机化学]
  • 相关文献

参考文献9

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二级参考文献19

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共引文献14

同被引文献8

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  • 8孙晓莉,匡永清,南鹏娟,张生勇.1,4-双(9-O-奎宁)-2,3-二氮杂萘的合成及其在烯烃不对称二羟基化反应中的应用[J].高等学校化学学报,2003,24(7):1216-1218. 被引量：10

引证文献1

中国医药工业杂志
2005年 第9期

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