摘要
AIM:To explore the abnormal function of platelets and the role of angelica sinensis injection(ASI)in patients with ulcerative colitis(UC).METHODS:In 39 patients with active UC,25 patients with remissive UC and 30 healthy people,α-granule membrane protein(GMP-140)and thromboxane B2(TXB2)were detected by means of ELISA,6-keto-PGF1αwas detected by radioimmunoassay,platelet count(PC)and 1min platelet aggregation rate(1min PAR)were detected by blood automatic tester and platelet aggregation tester respectively,and von Willebrand factor related antigen(vWF:Ag)was detected by the means of monoclonal-ELISA.The 64 patients with UC were divided into two therapy groups.After routine treatment and angelica sinensis injection(ASI)+routine treatment respectively for 3 weeks,all these parameters were also detected.RESULTS:The PC,1min PAR and levels of GMP-140,TXB2,and vWF:Ag in active UC were significanrly higher than those in remissive UC and normal controls(P<0.05-0.01).Meanwhile,1 min PAR and levels of GMP-140,TXB2,and vWF:Ag in remissive UC were still significantly higher than those in normal controls(P<0.05).Furthermore,6-keto-PGF1-αlevel in active and remissive UC was remarkably lower than that in normal control(P<0.05-0.01).These parameters except 6-keto-PGF1αwere significantly improved after the treatment in ASI therapy group(P<0.05-0.01),whereas they all were little changed in routine therapy group(P>0.05).CONCLUSION:Platelets can be significantly activated in UC,which might be related with vascular endothelium injury and imbalance between TXB2 and 6-keto-PGF1αin blood.ASI can significantly inhibit platelet activation,relieve vascular endothelial cell injury,and improve microcirculation in UC.
基金
Supported by Key Project in Scientific and Technological Researches of Hubei Province,No.2001AA308B
溃疡性大肠炎
血小板
当归注射液
药理作用
凝血噁烷B2
